Does Alpha-GPC Have Any Long-term Side Effects?

Written on November 21, 2022 by | Reviewed by William Gallagher, MNeuroSci

is a natural nootropic and cholinergic compound that has been shown to have numerous benefits for cognitive function.

These benefits include increased memory, improved mood, and reduced mental fatigue.

However, there are also some side effects that you should be aware of before taking Alpha-GPC.

Some of the side effects of Alpha-GPC may include hypertension and fluid retention if taken in excess amounts.

In this blog post, I'll discuss those side effects in-depth as well as the best way to use Alpha-GPC to avoid them.

So without further ado, let's begin...

How Things Go Bad As We Age

The brain is extremely sensitive to choline levels.

When there is an excess of the compound, it can cause nasty headaches and gastrointestinal issues.

This happens because Alpha-GPC converts into another chemical called trimethylamine (TMA) in our gut – which causes these negative reactions when we consume too much of it. ​

When it comes to brain health, choline is one of the most important nutrients.

It is a key precursor to acetylcholine – an essential neurotransmitter that helps us with memory and focus.

The problem lies in the fact that we produce less choline as we age… ​

As we get older, our brains start to lose the ability to produce enough acetylcholine.

This leads to cognitive decline and memory issues – which can be deadly.

For example, studies have shown that low choline levels are linked with Alzheimer's disease.

Alpha-GPC is the only form of choline that can easily cross from our blood into our brain.

That's why it is so effective at fighting memory loss and dementia – even in extremely healthy individuals. ​

Most Common Side Effects Long-term


Alpha-GPC is extremely safe – especially when taken by healthy adults.

It's even considered one of the safest nootropics on the market today. ​

The only common side effects are mild headaches and gastrointestinal discomfort caused by TMA buildup in our gut.

These symptoms go away within a few hours to a few days after we stop taking Alpha-GPC. ​

The best way to avoid these side effects is by increasing our choline intake slowly over at least 2 weeks starting with the minimum dose.

It also helps if you drink plenty of water with electrolytes and take in enough fiber from vegetables, fruits, and whole grains.

In some instances, people with certain health conditions may experience adverse effects when taking Alpha-GPC at high doses (1000mg+).

Don't mix it with other types of choline supplements either.

Alpha-GPC's Long-term Effects on The Brain

The long-term effects of Alpha GPC on cognition are still relatively unknown.

It's also not known whether or not these doses have any negative effects over the long term.

It's also not known whether or not these doses have any negative effects over the long term.

However, more studies are needed before we know what kind of impact this supplement will have on our brains in the future.

But for now, it seems like Alpha GPC is a safe and smart nootropic to try.