Andrographis Paniculata: The Perfect Health-Boosting Nootropic

Written on November 11, 2022 by | Reviewed by William Gallagher, MNeuroSci

Andrographis Paniculata is a powerful Nootropic that has been used in Indian Ayurvedic medicine for centuries as an herbal remedy to treat many health problems.

The plant contains compounds such as andrographolide, which is thought to be the primary active ingredient in Andrographis paniculata.

If you're looking for a natural way to improve your immune system and improve cognitive function, then Andrographis Paniculata may be perfect for you!

In this article, I'll take a closer look at the health benefits of Andrographis paniculata extract, and explain why it might be a perfect addition to your nootropic stack.

I'll also take you through how I recommend using this herbal remedy, which forms are best (pills, extracts), dosage recommendations, and any potential side effects you should know about before trying this Nootropic.

So let's get to it!

What is Andrographis Paniculata?

Andrographis Paniculata is an herb indigenous to India, Southeast Asia, and the Middle East.

It has been used for centuries in Ayurvedic medicine as a natural herbal remedy that is said to have many health benefits.

It's thought that Andrographis Paniculata may help lower cortisol levels naturally, which can be beneficial if you're feeling stressed or anxious.

Andrographis Paniculata is also thought to help with immune function and immunity in general, which can be helpful if you're looking for a natural way to boost your health or protect yourself from colds and other infections during the colder months of the year.

In traditional medicine, it's been used as an effective herbal remedy for respiratory issues and digestive problems.

One of the most interesting benefits that Andrographis Paniculata may have is its neuroprotective properties.

It has been shown to improve cognitive function in older adults with mild memory complaints over a period of 12 weeks - especially when taken alongside other Nootropics like Alpha-GPC (a choline source).

How does Andrographis Paniculata work as a Nootropic?

When it comes to improving cognitive function, Andrographis Paniculata can be beneficial for improving your memory and learning abilities.

Andrographolide is thought to work as an NMDA receptor modulator - which means it works by affecting the communication between neurons in your brain.

NMDA receptors are involved with many processes that take place within our brains, such as learning and the creation of new memories.

As Andrographis Paniculata extract can affect NMDA receptors, it makes sense that this Nootropic has been shown to improve cognitive function in older adults with mild memory complaints.

It's also thought to help lower cortisol levels naturally - which is great if you're looking for a natural way to reduce stress and anxiety.

As Andrographis Paniculata extract has been shown to help reduce cortisol levels naturally, this means you should find it easier to stay focused on the task at hand when taking Andrographis Paniculata supplements regularly.

You may also find that you're able to think more clearly, and process information better.

Andrographis Paniculata Extract is thought to work in a similar way to Huperzine A - another Nootropic known for improving memory retention and learning abilities.

How do I take Andrographis Paniculata?

If you're looking for a natural way to improve your health and boost cognitive function, then Andrographis Paniculata may be perfect for you!

Andrographis Paniculata supplements are easy to incorporate into your daily nootropic stack.

You can take this Nootropic as an extract or even in pill form.

Andrographis Paniculata extracts are said to be much more effective.

Just take 1000-2000mg daily alongside your other nootropic supplements for optimal results.

If you decide to try Andrographis Paniculata pills, then just make sure that they contain at least 50% andrographolide and no fillers.

It's also a good idea to take Andrographis Paniculata supplements alongside other Nootropics - especially choline sources like Alpha-GPC or CDP-Choline.

This will help your body absorb the herbal extract better, which means you should experience more benefits from taking Andrographis Paniculata.

An example of a daily nootropic stack would be Alpha-GPC or CDP-Choline, and Andrographis Paniculata extract.

With this combination, you can expect to experience improved memory retention and learning abilities - as well as lower cortisol levels naturally!

Andrographolide is also thought to work better when taken alongside other Nootropics like Piracetam and Aniracetam, which is why it's best to take Andrographis Paniculata supplements as part of a nootropic stack.

What dosage should I take?

As there isn't much research on the optimal dosage for Andrographis Paniculata, it's best to start off small.

Begin with taking 1000 mg of Andrographis Paniculata extract daily for the first week or so.

If you experience no negative side effects then increase your dosage by around 100mg every week until you reach your desired dose - which should be at least 1500 mg for best results.

What are the benefits of taking Andrographis Paniculata?

There's a number of studies that show how effective Andrographis Paniculata is for improving cognitive function and reducing stress levels naturally.

Here I've looked at 2 main ways this herbal extract can benefit you:

  1. Improving memory retention and learning abilities.
  2. Lowering cortisol levels naturally

When it comes to improving memory retention and learning abilities, Andrographis Paniculata has been shown to help with this in a number of studies.

A study found that Andrographolide reduces short-term memory loss, which may be caused both by stress and aging.

And another animal study showed that it helped with memory acquisition, consolidation, and retrieval.

There's also evidence that it improves attention span in healthy adults by increasing their ability to focus on the task at hand with no obvious side effects.

When it comes to Lowering cortisol levels naturally, Andrographis Paniculata has been found to reduce cortisol levels in both healthy adults and those with stress-related psychiatric conditions.

When taken for just 2 weeks at 800mg/day, cortisol levels were significantly lower than in the placebo group.

What are some negative side effects of taking Andrographis Paniculata?

In some rare cases, Andrographis Paniculata supplements may cause:

Headaches and nausea

When it comes to side effects, most people experience no negative ones when taking Andrographis Paniculata.

In fact, in the studies I mentioned above there were hardly any noticeable side effects at all - apart from a few reports of headaches and nausea.

However, if you do experience any negative side effects then it's best to discontinue use straight away.

That being said, one of the reasons why I recommend stacking with a choline source is so that you reduce your risk of experiencing headaches.

Choline sources like Alpha-GPC or CDP-Choline are not only excellent cholinergic Nootropics on their own - but they also prevent headaches when combined with Andrographis Paniculata.

The reason for this is because choline sources increase the amount of acetylcholine (ACh) in your body - which can help reduce headaches that are caused by low levels of this neurotransmitter.

In Summary

Andrographis Paniculata is an excellent nootropic supplement that has a number of benefits for your memory, learning ability, and stress levels.

It's also shown to be effective at reducing cortisol naturally - which can help improve moods as well as physical performance.

Due to the lack of research on optimal dosages, it's best to follow my dosage recommendations or those of the manufacturer.

Andrographis Paniculata is also known to cause some side effects in rare cases - but these are usually mild and go away on their own.

I recommend taking Andrographis Paniculata alongside a choline source like Alpha-GPC or CDP-Choline for even better cognitive benefits, as well as reduced risk of headaches.


What is Andrographis paniculata used for?

Andrographis paniculata is an herb that has been used in traditional medicine to cure viral illnesses and fevers for thousands of years. Andrographis has antibacterial, antioxidant, anti-inflammatory, anticancer, and immunostimulating activities.

What does Andrographis paniculata do for the body?

Andrographis paniculata helps with the immune system and is an antioxidant with hepatoprotective properties. It works by increasing the number of free radicals, which are uncharged molecules. This helps to strengthen defenses against infections and clean up toxins in the liver before they cause damage.

Is Andrographis paniculata an antibiotic?

The antibacterial activity of andrographolide has been demonstrated against common germs that are dangerous to human health. It is a broad-spectrum antibiotic and effective against a variety of bacteria.

Is Andrographis paniculata good for anxiety?

Andrographolide has been shown to possess anxiolytic activity. This means that it can help reduce feelings of anxiety and stress without causing drowsiness or fatigue which is sometimes associated with other anti-anxiety agents.

Is Andrographis paniculata edible?

Yes. Andrographis paniculata can be made into a tea or added to food, but the taste is said to be bitter and unpleasant.