Is Agmatine Sulfate a Stimulant?

Written on November 22, 2022 by | Reviewed by William Gallagher, MNeuroSci

Agmatine Sulfate is also known by some other names such as agmatine, 4-guanidine, and a few other names.

Basically, it is a metabolite derived out of Arginine and it, therefore, is an amino acid. It would not be right to classify Agmatine Sulfate as a BCAA and it is in no way related to the protein of any kind.

However, there are many who believe that it is helpful and offers some benefits.

Agmatine Sulfate is NOT considered to be a stimulant like caffeine. This also means that there are no crash-like effects. That being said Agmatine Sulfate does stimulate NOS-production which will stimulate and enhance blood flow (hence why people take it as a pre-workout supplement or brain enhancer.)

Agmatine is derived when it is allowed to go through a process of decarboxylation.

When Agmatine Sulfate is taken orally, it works in our guts. Our guts help in this substance go through the process of decarboxylation. Its main function is to impede the production of something known as NOS or Nitric Oxide Synthase. It does so by influencing three enzymes.

When these three enzymes are influenced they could do certain functions as far as our body is concerned. It could help in fighting harmful bacteria, and it could facilitate communication with the brain.

Primarily Agmatine Sulfate is used to treat patients who are looking for pain management. Hence it is useful for patients who suffer from different levels of chronic pain.

At the same time, it also works against certain classes of glutamate receptors and it helps the patients to have a different approach when it comes to perceiving pain.

Agmatine Sulfate Stimulant Crash

Agmatine Sulfate is generally considered to be safe with no risk of crashing.

That being said, some people have reported a negative impact on their mood post-workout.

Generally speaking, Agmatine Sulfate is well-tolerated and is not considered to be a stimulant, hence why you shouldn't experience any crash-like effects.

Agmatine Sulfate vs. Caffeine

When you choose Agmatine as a bodybuilding tool during workouts and pumping, quite often I see people asking whether it can be stacked with other ingredients.

There are many who are keen to know more about Agmatine vs. caffeine and a potential comedown/crash.

According to anecdotes and also some top trainers and bodybuilding professionals, combining caffeine along with agmatine sulfate is just fine and wouldn't result in a crash unless you take large amounts of caffeine or other similar stimulants.

This is because it could create the right supplement that is pumped up in the right sense of the term.

There are many who add a few more ingredients to the stack so that the required goals and purposes are achieved.

For example, if a person has some pre-existing health issues it would be better to be careful and check with his or her doctor before moving forward.

While agmatine sulfate is certainly a great product for managing a host of health-related issues, and also perhaps as a stimulant its credentials as a performance enhancer and bodybuilder still need to be studied in some more detail.