How Long Does It Take For Modafinil To Kick In?

Written on February 9, 2022 by | Reviewed by William Gallagher, MNeuroSci

I think it's safe to say that the most interesting Nootropic, or Smart Drug, on the market right now is Modafinil.

Clinical studies have shown it to have a wide range of nootropic capabilities, like enhanced memory, cognition and focus.

What's also unique about it is that, unlike other pharmaceutical smart drugs, it's not an amphetamine.

It's a wakefulness-promoting agent, but it does it by altering specific receptors in the brain rather than by upping the amount of dopamine and norepinephrine to produce a stimulating effect on the central nervous system.

In this article, I will be discussing the physiological and psychological effects of Modafinil, and will also cover the length of time it takes for Modafinil to kick in, how long it takes for it to reach peak blood concentration, and what you can do to make it work faster.

So without further ado, let's just jump straight into it, shall we?

When Does Modafinil Work?

How long does it take for it to begin working?

If you look at the half-life of Modafinil (the time it takes for a substance to lose 50% of its original concentration) then the average time taken to kick in is 15.1+/-5.3 hours, which is pretty good for any medicine.

But what about the peak blood concentration (the time taken for the maximum amount of Modafinil to be absorbed into the bloodstream)?

This happens anywhere between 1-4 hours.

Now, this isn't exactly a "peak" blood concentration, because the active ingredients have to build up in your blood until its peak levels are reached.

The good news is that it usually only takes about 2-3 hours for Modafinil to reach its peak concentration, so that means it generally takes less than 5 hours before you feel the effects of Modafinil.

How To Make Modafinil Work Faster

One of the best ways to make Modafinil work faster is to take a dose with a source of caffeine, like coffee.

This is because the two substances work synergistically, and both enhance each other when combined.

Caffeine will allow it to kick in much faster and stronger than it would alone.

Another way you can speed up the process even more is by taking it on an empty stomach.

Since caffeine is a diuretic it will act as a stimulator, and the Modafinil will act as an enhancer, so you can get quite an effective dose.

The trick is to take about 200mg of Modafinil, and then drink some coffee.

This way you'll still have about 4-5 hours before it reaches its peak blood concentration (within just 2-3 hours), but it should be enough to give you results.

Other Factors That Affect How Fast It Works

Aside from dosage, there are also metabolic factors that can affect how fast it takes for Modafinil to work.

For example, if you are a vegetarian, then you will need to take the time to adjust your diet to get enough protein in your diet because it takes longer for your body to break down proteins.

This is why most vegetarians often find that they get the best results when they combine this drug with caffeine.

You should also take into account age, weight, metabolism, diet and other factors that might affect your body.

That being said, this is not an exact science and all of your results will not be the same if you take this drug more than once.

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170336/ (A review on modafinil: the characteristics, function, and use in critical care)
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286657/ (Practical Use and Risk of Modafinil, a Novel Waking Drug)
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/ (Mechanisms of modafinil: A review of current research)
  4. https://pubmed.ncbi.nlm.nih.gov/16669720/ (A systematic review of modafinil: Potential clinical uses and mechanisms of action)
  5. https://pubmed.ncbi.nlm.nih.gov/23934211/ (The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders)