8 Best Nootropics For Weight Loss In 2022

Written on July 17, 2022 by | Reviewed by William Gallagher, MNeuroSci

In this article, I'll take a closer at the 8 best nootropics for weight loss. I'll also cover the potential risks and side effects you may run into as well as the benefits you can expect.

Are you looking for the best nootropics for weight loss in 2022?

If so, you've come to the right place.

You might be surprised to learn that nootropics can actually help with weight loss.

Although many people consider nootropics to be exclusively for cognition and memory enhancement, the truth is that they can also be incredibly effective for weight loss.

If you're looking to lose weight in 2022, here are 8 of the best nootropics for you to try.

The best nootropics for weight loss according to scientific evidence are:

  • Mind Lab Pro
  • Caffeine + L-theanine
  • Rhodiola Rosea
  • Modafinil
  • Adrafinil
  • Acetyl-L-Carnitine
  • L-Tyrosine
  • Omega-3

Let's take a closer look at each of these nootropics and how they can help you lose weight down below.

Mind Lab Pro

Mind Lab Pro consists of 11 clinically-proven nootropic ingredients that work together to improve cognitive function and mental performance.

But did you know that it can also help with weight loss?

Mind Lab Pro contains Rhodiola Rosea, which is an herb that's been shown to boost metabolism and promote fat loss [1]Pomari, Elena et al. “Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes.” Molecules (Basel, Switzerland) vol. 20,5 8409-28. 11 May. 2015, … Learn more.

Plus, it contains B-vitamins like B6 and B12, which have been shown to boost metabolism and promote weight loss [2]Zheng, Ying et al. “B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet.” Current medical science vol. 38,1 (2018): 174-183. … Learn more.

To top it off, Mind Lab Pro is vegan-friendly, non-GMO, and free from artificial colors, flavors, and preservatives. If you're looking for a natural nootropic that can help you lose weight, Mind Lab Pro is a great option.

Mind Lab Pros:

  • Helps you focus and stay on task
  • Improves cognitive function
  • Boosts mental performance
  • Can help with weight loss
  • Non-GMO
  • Vegan friendly

Mind Lab Pro Cons:

  • Can be expensive
  • Some people experience side effects
  • Not everyone will see results

Mind Lab Pro in Summary:

If you're looking for a nootropic that can help you lose weight and improve cognitive function, Mind Lab Pro is a great option.

It contains 11 clinically-proven nootropic ingredients that all work synergistically to give you an edge on your weight loss journey. Plus, Mind Lab Pro is vegan-friendly and free from artificial colors, flavors, and preservatives.

Caffeine + L-theanine

Caffeine is a well-known stimulant that can help you feel more awake and alert. It can also help you lose weight by boosting your metabolism and promoting thermogenesis [3]Dulloo, A G et al. “Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers.” The American journal of clinical nutrition vol. … Learn more.

L-theanine is an amino acid that can help to offset some of the side effects of caffeine, such as jitters and anxiousness [4]Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513.

L-theanine also has also been shown to activate the browning of white adipose tissue, which can help with weight loss [5]Peng, Wan-Qiu et al. “l-Theanine Activates the Browning of White Adipose Tissue Through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-Induced Obesity in Mice.” Diabetes vol. 70,7 … Learn more.

When you combine, or stack, caffeine, and L-theanine, you get a powerful nootropic stack that can help you lose weight while also improving cognitive function and focus.

Caffeine + L-theanine Pros:

  • Helps you feel more awake and alert
  • Boosts metabolism
  • Promotes thermogenesis
  • Can help you lose weight
  • Improves cognitive function and focus

Caffeine + L-theanine Cons:

  • Can cause side effects like jitters and anxiousness
  • May not be suitable for everyone

Caffeine + L-theanine in Summary:

If you're looking for a nootropic stack that can help you lose weight, caffeine + L-theanine is a great option.

Caffeine can help to boost your metabolism and promote thermogenesis, while L-theanine can offset some of the side effects of caffeine and also help to boost your metabolism.

Plus, this stack can also improve cognitive function and focus.

Rhodiola Rosea

Rhodiola Rosea is an herb that's commonly found in nootropic stacks. It's been shown to help with cognitive function, mood, and stress. But Rhodiola Rosea can also help with weight loss. It's been shown to help boost metabolism and promote thermogenesis [6]Anghelescu, Ion-George et al. “Stress management and the role of Rhodiola rosea: a review.” International journal of psychiatry in clinical practice vol. 22,4 (2018): 242-252. … Learn more.

If you're looking for a nootropic that can help you lose weight, Rhodiola Rosea is a great option.

Rhodiola Rosea Pros:

  • Can help with cognitive function, mood, and stress
  • Helps boost metabolism and promote thermogenesis
  • Can help reduce food cravings and appetite

Rhodiola Rosea Cons:

  • Some people may experience headaches
  • Can cause drowsiness in high dosages

Rhodiola Rosea in Summary:

If you're looking for a nootropic that can help you lose weight, Rhodiola Rosea is a great option.

It's been shown to help boost metabolism and promote thermogenesis, and it can also help reduce food cravings and appetite.

Modafinil

Modafinil is a well-known nootropic that's often used to improve cognitive function and increase energy levels. It's a wakefulness-promoting drug that's used to treat narcolepsy and other sleep disorders [7]Greenblatt, Karl. and Ninos Adams. “Modafinil.” StatPearls, StatPearls Publishing, 22 February 2022.

But Modafinil has also shown promising weight loss results in clozapine-treated schizoaffective disorder patients [8]Henderson, David C et al. “Modafinil-associated weight loss in a clozapine-treated schizoaffective disorder patient.” Annals of clinical psychiatry : official journal of the American Academy of … Learn more

Plus, Modafinil has also been shown to decrease food intake in humans subjected to simulated shift work [9]Perez, Gydmer A et al. “Modafinil decreases food intake in humans subjected to simulated shift work.” Pharmacology, biochemistry, and behavior vol. 90,4 (2008): 717-22. … Learn more.

Modafinil Pros:

  • Improves cognitive function and wakefulness
  • Increases energy levels
  • Helps boost metabolism and promote thermogenesis
  • Can help reduce food cravings and appetite

Modafinil Cons:

  • Can cause side effects like headaches and insomnia
  • May not be suitable for everyone

Modafinil in Summary:

Modafinil is a great option for a nootropic that can help you lose weight.

It is also a very powerful eugeroic that can help to increase energy levels, motivation, and focus.

It can also help to suppress appetite and reduce cravings. Overall, modafinil is an excellent option for those looking for a nootropic to help with weight loss.

Adrafinil

Adrafinil is a eugeroic which means it promotes wakefulness and alertness. It was originally developed to treat narcolepsy and other sleep disorders but is commonly used off-label as a cognitive enhancer [10]Siwak, C T et al. “Adrafinil: effects on behavior and cognition in aged canines.” Progress in neuro-psychopharmacology & biological psychiatry vol. 24,5 (2000): 709-26. … Learn more.

Adrafinil is structurally similar to modafinil and works by increasing dopamine and norepinephrine levels in the brain. These neurotransmitters are known to play a role in regulating appetite and metabolism.

Adrafinil Pros:

  • Promotes wakefulness and alertness
  • Increases dopamine and norepinephrine levels
  • May help with weight loss

Adrafinil Cons:

  • Can cause side effects like anxiety and insomnia
  • May not be suitable for everyone

Adrafinil in Summary:

If you're looking for a nootropic that can help you lose weight, Adrafinil is a great option. It's a eugeroic that promotes wakefulness and alertness, and it also increases dopamine and norepinephrine levels in the brain. These neurotransmitters are known to play a role in regulating appetite and metabolism.

Overall, Adrafinil is an excellent nootropic for those looking to lose weight.

Acetyl-L-Carnitine

Acetyl-L-carnitine (ALCAR) is an amino acid that's naturally produced in the body. It's involved in energy production and has numerous other health benefits.

ALCAR has shown promise as a weight loss supplement. One study showed that ALCAR at 2000 mg per day was effective at reducing body weight, BMI, and fat mass in obese adults [11]Talenezhad, Nasir et al. “Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with … Learn more.

Acetyl-L-Carnitine Pros:

  • A natural amino acid that's involved in energy production
  • Shown to be effective at reducing body weight, BMI, and fat mass
  • Cheap and easy to get your hands on

Acetyl-L-Carnitine Cons:

  • May cause side effects like nausea and stomach upset
  • May not be suitable for everyone

Acetyl-L-Carnitine in Summary:

Acetyl-L-carnitine is a great option for those looking for a natural nootropic to help with weight loss.

It's involved in energy production and has been shown to be effective at reducing body weight, BMI, and fat mass. It's also cheap and easy to get your hands on.

L-Tyrosine

L-Tyrosine is an amino acid that the body uses to produce dopamine, norepinephrine, and epinephrine - neurotransmitters that are important for mood, focus, and energy.

L-Tyrosine has been shown to help improve cognitive performance under stress, and it is often used as a natural supplement to boost mood and energy levels.

A study showed that tyrosine might be a potential therapy for cognitive and mood problems associated with the maintenance of reduced body weight [12]Hao, S et al. “Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: effects of tyrosine.” Pharmacology, biochemistry, and behavior vol. 68,2 (2001): … Learn more.

L-Tyrosine Pros:

  • Helps produce dopamine, norepinephrine, and epinephrine
  • Shown to improve cognitive performance under stress
  • May help with weight loss

L-Tyrosine Cons:

  • Can cause side effects like anxiety and headaches

L-Tyrosine in Summary:

L-Tyrosine is an amino acid that plays an important role in the production of dopamine and other catecholamines. It has been shown to improve cognitive performance under stress.

L-Tyrosine has also been shown to regulate mood in people who are trying to lose weight. If you're looking for a nootropic to help with weight loss, L-Tyrosine is a great option.

Omega-3

Omega-3s are a type of unsaturated fat that has been shown to have a number of health benefits, including weight loss. One of the ways omega-3s promote weight loss is by decreasing inflammation.

Inflammation is a key factor in the development of obesity, and omega-3s help to reduce inflammation throughout the body. In addition, omega-3s also help to regulate metabolism and reduce appetite.

One study found that participants who took omega-3 supplements lost more weight than those who did not take the supplements [13]Du, Shichun et al. “Does Fish Oil Have an Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials.” PloS one vol. 10,11 e0142652. 16 Nov. 2015, … Learn more.

Omega-3s can be found in a variety of foods, such as fish, nuts, and seeds, making them an easy way to incorporate into your diet.

Omega-3 Pros:

  • Decreases inflammation
  • Regulates metabolism
  • Reduces appetite

Omega-3 Cons:

  • May cause side effects like indigestion and nausea

Omega-3 in Summary:

Omega-3s are a type of unsaturated fat that has been shown to promote weight loss by decreasing inflammation, regulating metabolism, and reducing appetite.

You can find omega-3s in a variety of foods, making them an easy way to incorporate into your diet.

What Are the Best Nootropics for Weight Loss?

The best nootropics for weight loss are those that help to reduce inflammation, regulate metabolism, and reduce appetite.

Omega-3s, L-Tyrosine, and Acetyl-L-Carnitine are all great options that can help you lose weight and keep it off. Also, nootropic blends can help to support weight loss by providing you with the nutrients you need to stay on track.

If you're searching for the best nootropics for weight loss, I recommend looking at Mind Lab Pro. It's a comprehensive nootropic that provides you with everything you need to support weight loss.

In addition, Mind Lab Pro also contains a number of other ingredients that can help to improve cognitive function and protect the brain.

How to Choose the Right Nootropic Supplement for Weight Loss?

You choose the right nootropic supplement for weight loss by looking at the specific ingredients and compare them to your goals.

Nootropics that address inflammation, metabolism, and appetite will be the most effective for weight loss.

As I mentioned above, omega-3s, L-Tyrosine, and Acetyl-L-Carnitine are all great options that can help you lose weight. Also, nootropic blends can be helpful because they contain a more complete range of nutrients.

In addition, you want to ensure that the supplement you choose is safe and does not contain harmful ingredients. This can be done by looking at the label and checking the website for more information.

I also recommend reading reviews before buying a nootropic supplement. This way, you can get an idea of what other people have experienced.

What Are the Benefits of Nootropics for Weight Loss?

The benefits of nootropics for weight loss include:

  • Reducing inflammation
  • Regulating metabolism
  • Reducing appetite
  • Keeps your mood up
  • Improving cognitive function

Depending on which nootropics you choose, there are a variety of other benefits that can be helpful when trying to lose weight.

For example, omega-3s help with weight loss, support cognitive function and protect the brain. L-Tyrosine can also improve mood and cognitive function.

In addition, some nootropics can help to improve energy levels and motivation, making it easier to stick to your weight loss goals.

What Are the Side Effects of Nootropics for Weight Loss?

The side effects of nootropics for weight loss depend on the specific ingredients.

Omega-3s, for example, are generally well-tolerated but can cause side effects like indigestion and nausea in some people.

L-Tyrosine is also generally well-tolerated but can cause side effects like headaches, stomach upset, and anxiety in some people.

Acetyl-L-Carnitine can cause side effects like nausea, vomiting, and stomach upset. It's important to start with a lower dose and increase gradually to avoid these side effects.

That being said, there is also a big difference between natural and synthetic nootropics. Natural nootropics are generally much safer and have fewer side effects.

Synthetic nootropics, on the other hand, can cause a variety of serious side effects and requires a prescription most of the time.

Do Nootropics Really Work for Weight Loss?

Nootropics work for weight loss by addressing different mechanisms in the body. These mechanisms include inflammation, metabolism, and appetite.

Nootropics that target these can be effective for weight loss.

That being said, it's important to remember that nootropics are not a miracle cure and will not work if you do not make other lifestyle changes.

For example, if you're not eating a healthy diet or exercising regularly, nootropics will not be able to help you lose weight.

Final Thoughts on Nootropics for Weight Loss

So the final question then becomes: do nootropics work for weight loss?

The answer is yes, but they are not a miracle cure. Nootropics can help address different mechanisms in the body involved in weight loss.

However, they will not be effective if you do not make other lifestyle changes like eating a healthy diet and exercising regularly.

If you're looking for a little extra help to lose weight, nootropics could be a good option for you. Just make sure to choose the right nootropic supplement and start with a lower dose to avoid any side effects.

If you're looking for nootropics for weight loss, I highly recommend looking into Mind Lab Pro, which is a safe and effective nootropic blend.

References

References
1Pomari, Elena et al. “Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes.” Molecules (Basel, Switzerland) vol. 20,5 8409-28. 11 May. 2015, doi:10.3390/molecules20058409
2Zheng, Ying et al. “B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet.” Current medical science vol. 38,1 (2018): 174-183. doi:10.1007/s11596-018-1862-9
3Dulloo, A G et al. “Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers.” The American journal of clinical nutrition vol. 49,1 (1989): 44-50. doi:10.1093/ajcn/49.1.44
4Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
5Peng, Wan-Qiu et al. “l-Theanine Activates the Browning of White Adipose Tissue Through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-Induced Obesity in Mice.” Diabetes vol. 70,7 (2021): 1458-1472. doi:10.2337/db20-1210
6Anghelescu, Ion-George et al. “Stress management and the role of Rhodiola rosea: a review.” International journal of psychiatry in clinical practice vol. 22,4 (2018): 242-252. doi:10.1080/13651501.2017.1417442
7Greenblatt, Karl. and Ninos Adams. “Modafinil.” StatPearls, StatPearls Publishing, 22 February 2022.
8Henderson, David C et al. “Modafinil-associated weight loss in a clozapine-treated schizoaffective disorder patient.” Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists vol. 17,2 (2005): 95-7. doi:10.1080/10401230590932407
9Perez, Gydmer A et al. “Modafinil decreases food intake in humans subjected to simulated shift work.” Pharmacology, biochemistry, and behavior vol. 90,4 (2008): 717-22. doi:10.1016/j.pbb.2008.05.018
10Siwak, C T et al. “Adrafinil: effects on behavior and cognition in aged canines.” Progress in neuro-psychopharmacology & biological psychiatry vol. 24,5 (2000): 709-26. doi:10.1016/s0278-5846(00)00103-2
11Talenezhad, Nasir et al. “Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis.” Clinical nutrition ESPEN vol. 37 (2020): 9-23. doi:10.1016/j.clnesp.2020.03.008
12Hao, S et al. “Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: effects of tyrosine.” Pharmacology, biochemistry, and behavior vol. 68,2 (2001): 273-81. doi:10.1016/s0091-3057(00)00448-2
13Du, Shichun et al. “Does Fish Oil Have an Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials.” PloS one vol. 10,11 e0142652. 16 Nov. 2015, doi:10.1371/journal.pone.0142652