Fladrafinil: Everything You Need To Know (Benefits & Risks)


In this article I’ll take a closer look at; Fladrafinil (or fluorafinil) which is a popular eugeroic in the biohacking-sphere. I’ll cover some background information, its benefits and risks, and finally reveal if I would recommend it.


First off, what is Fladrafinil?

Fladrafinil is a nootropic of the eugeroic class. It has been shown to improve cognitive function in healthy adults with little to no side effects. The drug acts as a selective wakefulness promoting agent.

This means it will increase wakefulness and energy levels in healthy adults. It also enhances cognitive function by enhancing the effects of adenosine.

Adenosine is a chemical messenger in the brain that inhibits wakefulness, so an increase in its concentration will enhance wakefulness and energy levels.


How does it work?

As I’ve mentioned, Fluorafinil acts as a Selective Wakefulness Promoting Agent. What this means is it will cause the user to feel more awake and energetic.

It is thought that the drug may act on receptors that inhibit adenosine in the brain, and so allow adenosine to increase. The mechanism for how this occurs is not fully understood.



The effects the drug has on individuals will be different. In general, healthy adults report that it increases energy levels, wakefulness, focus, and motivation. Also, users may report enhanced cognition and a sense of well-being and euphoria.

Users can expect to feel more alert without feeling overstimulated. It is not something that should be taken as a stimulant such as Adderall or modafinil, it is more of a natural energizing agent without the jitters or risk of crash/jitters than other stimulants have. In other words, it is not thought to be addictive.

Despite the potential benefits, there has been some controversy over Fladrafinil. In particular, many people have reported that the drug can cause insomnia.

This is thought to be due to the nootropic acting on adenosine receptors in the brain. The chemical is thought to make it difficult for users to fall asleep and stay asleep.  Using other medications such as melatonin may help overcome this.  Some people will find themselves unable to use Fladrafinil as a result of this.

On the flip side, some users have reported that Fladrafinil does not affect them in this way but only improves their sleep quality.


How effective is Fladrafinil?

Fladrafinil has been shown to have the potential to help users stay awake. A decrease in sedation and feelings of fatigue are common. In fact, a study found that 40 mg of the drug helped users stay awake on monotonous tasks. Also, they felt more energetic and motivated to complete the task.

There is growing evidence that suggests Fladrafinil may improve cognition as well. A 2010 study examined its effects on cognitive ability in healthy adults while performing monotonous tasks. It was found that it enhanced planning ability, clarity of thought, and mental performance during cognitive tests making it suitable for maintaining wakefulness.


Adrafinil vs Fladrafinil – What’s the difference?

To begin with, it is important to understand that Fladrafinil and Adrafinil are similar in some ways, but also very different in others.

Adrafinil is considered a prodrug of Fladrafinil. This means that it can be ingested to then be metabolized into Fladrafinil in the body. Through this method, users are able to bypass the first-pass metabolism system of the liver and so increase bioavailability.

In terms of what they do, they are pretty similar.  Both have been shown to be effective nootropic cognitive enhancers that can improve wakefulness and reduce fatigue in users. Although both drugs appear to provide very similar benefits and side effects, there are some key differences.

The half-life of Adrafinil is around 1 on average, whereas Fluorafinil is around 2 hours. A shorter half-life means that it will wear off more quickly meaning more frequent dosing is necessary. In fact, some users report having to take Adrafinil multiple times per day.

High doses of Adrafinil can lead to side effects such as headaches and nausea. These are thought to be due to the drug’s ability to increase serotonin levels in the brain. Fluorafinil has not been shown to have this effect on serotonin levels and so some of these side effects may not occur with it.

In theory, Fladrafinil should have a higher potency than Adrafinil due to its longer half-life. This means it could improve wakefulness for longer. However, this difference may not be significant for individuals with a lower tolerance and/or sensitivity to the drug.


Dosage & where to buy online

Anyone taking Fladrafinil should stick to the recommended dosage which is between 50 mg and 200 mg per day. Anything above this can cause unwanted side effects due to its long half-life meaning it can stay in your system for longer.

For new users start off at a low dose of around 50 mg/day which you can then increase as you get used to the drug over time. Some people will start off with a higher dose as they don’t feel the effects as well in the early stages.

To take Fladrafinil, simply swallow a small capsule of 50 mg or 100 mg.  Make sure to take it with a full glass of water and wait for up to 2 hours before going to bed.  If you do experience any side effects these should pass within a few hours and you can then reduce your dosage accordingly over time.

Fladrafinil is not highly regulated in most countries although it is useful to check this before sourcing your supply. You can buy it over the counter or online.

If you don’t want to risk getting in trouble with the law you can find a better alternative to Fladrafinil here.


In summary

Adrafinil and Fladrafinil are both useful nootropic drugs with similar effects and side effects. They are both effective nootropic drugs that promote wakefulness, improve mental clarity and reduce fatigue.

The main difference is that Adrafinil must be ingested and then metabolized by the body to then produce Fladrafinil. This means that it can be more difficult to get the right doses and may impact some of its effects.

Fladrafinil on the other hand can be ingested directly as it is already in the active form so may be easier to use as a nootropic cognitive enhancer for many people.


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