9-Me-Bc Review: Benefits, Side Effects & Where To Buy

Written on January 10, 2024 by | Reviewed by William Gallagher, MNeuroSci

In this 9‐Methyl‐β‐carboline review, I'll be looking at what 9-me-BC is, how it works and what it's used for. I'll go over the benefits, the perfect dosage, and what side effects you may run into. Lastly, I'll share my own experience with it and where you can buy 9-me-BC online.

Are you looking for a powerful nootropic to enhance cognitive function?

9-Methyl-beta-carboline (9-me-BC) is a research chemical that has shown potential for enhancing cognitive function.

It’s still relatively new on the market, but early studies suggest it could be a powerful tool in your arsenal for boosting productivity and mental performance.

Let's take a closer look at 9-me-BC down below and see if it lives up to all the hype, shall we?

What Is 9-me-BC?

what-is-9-me-bc
Name9-Me-BC (9-Methyl-β-carboline)

ClassNootropic compound (a research chemical)
EffectsCognitive enhancer & increases euphoria
Side Effects
Headaches and sensitivity to sunlight
Half-Life
15-24 hours
Dosage15-30 mg daily
Content
30ml/17mg per ml/500mg
Price$50.48

9-Me-BC is a heterocyclic amine of the β-carboline family. It is also known as 9-methylene-beta-carboline, 9-Methyl-9H-β-carboline, 9-Methylnorharman, 9-MBC and N-Methyl-β-carboline

9-Methyl-beta-carboline (9-me-BC) is a research chemical with a wide range of potential nootropic benefits. It's structurally similar to beta-carbolines like harmine and harmane, which are found in various plants.

These chemicals have been used for centuries in traditional medicine for their psychoactive properties according to a medical review.[1] It has been shown to have various pharmacological effects, including inhibition of monoamine oxidase (MAO), antioxidant activity, and neuroprotection.

It's a methylated derivative of β carboline with the molecular formula: C12H10N2. 9-me-BC was first isolated in the 1970s and its pharmacological effects have been studied extensively since then. 9-methyl-β-carboline has a wide range of activities that might be helpful in treating Parkinson's Disease, Alzheimer's, and other cognitive disorders.

According to a study published in the peer-reviewed Journal of Neurochemistry, 9-me-BC was shown to stimulate dopaminergic neurons[2] by boosting tyrosine hydroxylase and transcription factors in pre-existing dopa decarboxylase immunoreactive neurons, which increases the amount of dopamine produced.

An animal study published in the Journal of Neural Transmission also found that 9-methyl-β-carboline has survival and regenerative/restorative potential for dopaminergic neurons by modulating the expression of multiple neurotrophic proteins as well as decreasing apoptotic cell signals.[3]

Chemical Information

Trade Names9-Me-BC & 9-MBC
IUPAC Name
5-Methyl-5H-pyrido[3,4-b]indole
Other Names
9-Me-BC
9-Methyl-9H-β-carboline
9-Methylnorharman
9-MBC
N-Methyl-β-carboline
CAS Number
2521-07-5
Molecular Formula
C12H10N2
Molecular Weight
182.226 g·mol−1
PubChem CID164979

Mechanism of Action: How Does 9-me-BC Work?

9-me-BC's mechanism of action is thought to work by inhibiting monoamine oxidase (MAO). MAO is an enzyme that breaks down monoamines, which are neurotransmitters that play an important role in mood and cognition.

mechanism_of_Action

Inhibition of MAO results in increased levels of monoamines in the brain, which leads to improved cognitive function. 9-me-BC is also a potent antioxidant and has neuroprotective effects. It scavenges free radicals and protects neurons from damage, which might help to preserve cognitive function in the aging brain.

9-me-BC, when taken as a supplement, has been shown to increase the rate of neurotrophin synthesis, which is important for cognitive function. This action is linked to dendritic, synaptic growth, and enhanced ATP synthesis.

  • Dendrites are the branching extensions of neurons that receive signals from other neurons.
  • Synapses are the gaps between cells where chemical signals are transmitted.
  • ATP is the energy currency of the cells.

All of these mechanisms work together to improve cognitive function. According to Food and Chemical Toxicology, a peer-reviewed scientific journal, 9-me-BC has also been shown to increase levels of BDNF,[4] which is a protein that helps to support the health of neurons. BDNF plays an important role in learning and memory, and low levels have been linked to cognitive decline.

9-me-BC also decreases inflammation in the brain, which is thought to contribute to its cognitive-enhancing effects.

In summary:

9-me-BC works by stimulating neurons as well as promoting their growth. It's neuroprotective, which means it protects our brain and central nervous system from toxin-induced damage.

It has a variety of effects, which may be due to its several mechanisms of action:

  • Interacting with the dopamine synthesis pathway via the tyrosine hydroxylase enzyme
  • The monoamine oxidase A and B (MAOA and MAOB) are both inhibited by harmaline, which is why it works as an MAOI.
  • It inhibits the breakdown of dopamine, resulting in higher levels of dopamine.

9-Me-BC is a dopaminergic compound as well. This basically implies that it increases dopamine-linked activity in the brain.

9-Me-BC and Inflammation

Inflammatory processes are involved in the degeneration of dopaminergic neurons, and anti-inflammatory medications have been linked to a reduced risk of Parkinson's disease (and Alzheimer's disease). 9-Me-BC is anti-inflammatory, in addition to its neurotrophic and neuroprotective effects on dopaminergic neurons.

It inhibits the generation of pro-inflammatory cytokines, as well as chemotactic cytokines (which are involved in the migration of immune cells). It also prevents the proliferation of microglia (immune cells in the brain that can damage neurons).

What Is 9-me-BC Used For?

9-me-BC is used for its potential cognitive-enhancing effects. It is often used as an alternative to Racetams and other psychoactive substances.

People use 9-me-BC to achieve:

  • Better executive functioning and alertness
  • Enhanced cognition
  • Improved Mitochondrial function
  • Improved mood

What Are the Benefits of 9-me-BC?

According to clinical studies, 9-me-BC has the following benefits: Neuroprotection, improved cognitive function, increased levels of BDNF, increased neurotrophin synthesis, and anti-inflammatory effects. Let's take a closer look at the benefits down below.

Neuroprotection and Improved Cognition

One of the most well-established benefits of 9-me-BC is its neuroprotective effects.

9MeBC also enhances cognition on tasks involving short-term memory, such as forming new memories and recalling.

Dendritic and Synaptic Proliferation

A study published in the Journal of Neurochemistry showed that 9-Me-BC was associated with elevated levels of dopamine in the hippocampus, as well as dendritic and synaptic proliferation.[5]

Elevated levels of dopamine, as well as dendritic and synaptic proliferation, have also been associated with memory and learning.

This suggests that 9-Me-BC may help to improve memory and learning by increasing dopamine levels in the hippocampus.

Anti-inflammatory effects

9-me-BC also has anti-inflammatory effects. In one study, it was found to decrease the production of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines in human keratinocytes.

It's hypothesized that these effects are mediated by the inhibition of NF-kB, which is a protein that plays a role in the inflammatory response.

9-me-BC Reviews & Experiences Reported On Reddit

When it comes to 9-me-BC reviews from people who have tried it, the reports are largely positive. I've taken a deep dive into the Reddit nootropics community to find out what people are saying about 9-me-BC.

Here's what people on Reddit say about 9-me-BC:

"I've been taking 9-me-BC for a few weeks now and I'm really liking it. I'm definitely noticing an increase in energy and focus." - Reddit User #1

“I’ve been using 9-me-BC for a few weeks now and I’ve noticed a significant increase in my cognitive function. I would definitely recommend it to anyone looking for a natural way to improve their cognitive function.” Reddit User #2

“9-me-BC is definitely one of the best nootropics I’ve tried. I’ve been taking it for a few weeks now and I’ve noticed a significant increase in my energy levels and focus. I would definitely recommend it to anyone looking for a natural way to improve their cognitive function.” - Reddit User #3

Some Reddit users discuss the benefits, potency, and side effects of 9-Me-BC here:

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side_effects_9-me-bc
benefits_9-me-bc

My Personal 9-me-BC Experience & Results

A couple of weeks ago I decided to finally buy some 9-me-BC after doing a lot of research on it and reading a lot of reviews from people who had tried it.

I've been taking it for about 2 weeks now and I'm definitely noticing some positive effects.

Here's what I've personally noticed:

  • Increased energy levels
  • More alert and focused
  • Some slight euphoria

One of the things I really noticed on 9-me-BC is the euphoria. It reminds me a bit of the 'come up' you get when taking Phenibut but not as potent though.

I took 15 mg daily for the first week and then bumped up my dosage to 25 mg which seems to be the sweet spot for me.

How Does 9-me-BC Feel Like?

One of the things I noticed while taking 9-me-BC was the Euphoria. It reminded me a lot of Phenibut, though not as strong. I also felt more alert with effects similar to what you will experience while taking Adrafinil or Modafinil.

Other than that I didn't really notice any negative side effects or crashes.

Where to Buy 9-me-BC Online?

You can buy 9-me-BC online from PureRawz. You can find 9-me-BC liquid right here:

Price: How Much Does 9-me-BC Cost?

As you can see the 500 mg 9-me-BC liquid costs $50.48 bucks with same-day shipping and a 100% satisfaction guarantee.

What Are the 9-me-BC Side Effects?

9-me-BC has few side effects. Those side effects are:

  • Skin irritation
  • Slight increase in body temperature
  • Headache
  • Dopamine neurotoxicity
  • Dizziness
  • Anxiety

How to Take 9-me-BC?

9-Me-BC is most commonly swallowed in capsules, but it can also be purchased as a powder or liquid. 9-Me-BC usually takes effect after around an hour. No matter how you take 9 Me BC, it's important to start with a low dose and see how you react before taking more.

I recommend taking 9-Me-BC on an empty stomach in the morning. If you experience any negative effects, you can split your dosage taking one in the morning and one in the afternoon.

What Is the Recommended 9-Me-BC Dosage?

DosageAmount
Low15 mg daily
Recommended20 mg daily
High30+ mg daily

The recommended 9-Me-BC dosage is anywhere from 15 to 30 mg daily. Some users have taken as much as 50 mg daily without any negative side effects.

What Is 9-Me-BC's Half-Life?

9-Me-BC has a half-life of 15-24 hours depending on the dosage. A drug's half-life is the amount of time it takes for the concentration of the drug in the body to be reduced by half.

The half-life of a drug can vary depending on a number of factors, including the person's age, weight, and metabolism.

Drugs with a shorter half-life are typically metabolized more quickly by the body and have a shorter duration of action. drugs with a longer half-life may take longer to be metabolized and may have a longer duration of action.

The half-life of a drug is an important consideration when determining how often it should be taken and how long it will remain in the body.

Does 9-Me-BC Create Tolerance?

Like all psychoactive substances, nootropics like 9-Me-BC can lead to tolerance build-up. This means that the user will need to take increasingly large doses to achieve the same effect. In some cases, this can lead to dependency and addiction.

Therefore, it is important to be aware of the potential risks before taking any nootropics, 9-Me-BC included. If you want to avoid building a tolerance to 9-Me-BC, there are a few things that you can do to avoid this from happening:

Firstly, cycle your 9-Me-BC so that you are not taking it every day. This will give your body a chance to recover and avoid developing a tolerance.

Secondly, make sure that you are using a variety of different nootropics rather than relying on just one. This will help to avoid developing a tolerance to any one particular substance.

Finally, be sure to start off with a low dose and increase gradually over time. This will allow your body to adjust to the effects of the nootropics and reduce the likelihood of developing a tolerance.

By following these simple tips, you can avoid developing a tolerance to 9-Me-BC.

Major Drug Interactions: What Does 9-Me-BC Interact With?

There is still a lot to learn about 9-Me-BC and its potential drug interactions. However, there are some significant drug interactions that have been identified. 9-Me-BC may interact with certain blood pressure medications such as Amlodipine, Diltiazem, and Felodipine.

If you are taking any medication for high blood pressure, it is important to speak to your doctor before starting 9-Me-BC. 9-Me-BC may also interact with dopaminergic drugs like Levodopa and antidepressants.

What Are the Best 9-Me-BC Stacks?

When stacked with other nootropics, 9-ME-BC can be even more effective.

The best 9-ME-BC stacks include:

  1. Sulbutiamine + 9-Me-BC
  2. Piracetam + 9-Me-BC
  3. Alpha-GPC + 9-Me-BC

Sulbutiamine is a nootropic that increases energy and improves mood. Piracetam is a nootropic that increases cognitive function and memory.

Alpha-GPC is a natural nootropic compound that is found in the brain. It is a precursor to acetylcholine, a neurotransmitter involved in memory, learning, and other cognitive processes.

What is The Best 9-Me-BC Alternative?

When it comes to 9-Me-BC there are a bunch of different alternatives. Let's take a closer look at one of the most popular 9-Me-BC alternatives down below:

9-Me-Bc vs. Bromantane

Bromantane, also known as Ladasten, is a medication used to treat fatigue and cognitive impairment. It was developed in Russia in the 1980s and has since been approved for use in that country. Bromantane is thought to work by increasing the release of dopamine and norepinephrine, two neurotransmitters that are involved in arousal and attention.

Bromantane has also been shown to increase levels of BDNF, a protein that helps to promote neuronal growth and plasticity and many users report feeling the effects of Bromantane more clearly when compared to 9-Me-Bc.

Another reason why some people chose Bromantane over 9-Me-Bc is that 9-Me-Bc can make your skin more sensitive to the sun, and in some cases, it can cause a burning sensation. If you are looking for an alternative to 9-Me-Bc that does not have this side effect, Bromantane may be a better choice for you.

Scientific 9-Me-Bc Research

Let's take a look at what the science says about 9-Me-Bc.

Animal Studies

The 2012 study done on rats by M. Gruss et al. published in the Journal of Neurochemistry looked at the stimulatory effects of 9-me-BC to test the hypothesis that 9-me-BC may act as a cognitive enhancer. Here's what they concluded:

We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation... Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.

Frequently Asked Questions (FAQ)

How Long Does It Take For 9-Me-Bc to Kick In?

9-Me-Bc usually kicks in within an hour. That being said, the benefits of 9-Me-Bc are really noticeable after a week of daily use at 15-30 mg a day.

How Long Does 9-Me-Bc Last?

According to the study done on rats, the effects were noticeable up to 10 days after administration. Since the data on 9-Me-Bc in humans is very limited, all we can do is use anecdotal evidence - most people can feel the effects of 9-Me-Bc for up to 15 hours.

What Does 9-Me-Bc Taste Like?

9-Me-Bc comes in a tasteless, and unflavored, powder and liquid form.

Is 9-Me-Bc Safe?

The data on 9-Me-Bc's safety is very limited, however, it does not seem to have any serious side effects. The most common side effects people experience while taking 9-Me-Bc are: Headaches and sensitivity to light.

Is 9-Me-Bc Legal & FDA-Approved?

9-Me-Bc is a research chemical that is not currently banned in most countries. That being said, the FDA has not approved it for any use.

Final Thoughts: Is 9-Me-Bc Worth It?

In my personal experience, 9-Me-Bc works amazingly on its own and is definitely worth it.

That being said, I would not recommend stacking it with any other nootropics.

If you are looking for a powerful, and effective nootropic - 9-Me-Bc is worth trying out.

Keep in mind that when it comes to the scientific research on 9-Me-Bc, the data is very limited.

So, if you decide to take it, please do so with caution, start with a lower dose to see how you react to it, and always consult with a doctor if you have any questions or concerns.

References
  1. Airaksinen, M M, and I Kari. “beta-Carbolines, psychoactive compounds in the mammalian body. Part II: Effects.” Medical biology vol. 59,4 (1981): 190-211. 
  2. Polanski, W., Enzensperger, C., Reichmann, H., & Gille, G. (2010). "The exceptional properties of 9-methyl-β-carboline: Stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects." Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2010.06725.x 
  3. Keller, S., Polanski, W. H., Enzensperger, C., Reichmann, H., Hermann, A., & Gille, G. (2020). "9-methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes." Journal of Neural Transmission, 127(7), 999–1012. https://doi.org/10.1007/s00702-020-02189-9 
  4. Herraiz, T., & Guillén, H. (2011). "Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors." Food and Chemical Toxicology, 49(8), 1773–1781. https://doi.org/10.1016/j.fct.2011.04.026 
  5. Gruss, M., Appenroth, D., Flubacher, A., Enzensperger, C., Bock, J., Fleck, C., Gille, G., & Braun, K. (2012). "9-methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation." Journal of Neurochemistry, 121(6), 924–931. https://doi.org/10.1111/j.1471-4159.2012.07713.x