What Is The Difference Between Fladrafinil And Flmodafinil?

Updated July 1, 2024 by | Reviewed by William Gallagher, MNeuroSci
(Estimated reading time: 3 minutes)

Fladrafinil vs Flmodafinil - how do they compare?

So recently I came across two interesting Smart Drugs on Reddit searching for some information about Adrafinil and Modafinil.

I actually had no idea about them and what they do, so I figured, why not write an article about them in order to figure both of them out. Fladrafinil vs Flmodafinil - what's the difference? Let's find out.

Fladrafinil Overview

Fladrafinil is also known as CRL-40,941 or Fluorafinil. It is a eugeroic related to Adrafinil and Modafinil.

A eugeroic is a drug that promotes wakefulness and alertness which is why people often stumble upon Fladrafinil, like me, when researching Adrafinil and Modafinil.

From what I could find, Fladrafinil was first synthesized back in the '70s and was later patented in France in the late '80s.

People taking Fladrafinil report similar effects as Modafinil and Adrafinil although some argue that Fladrafinil is a more potent eugeroic compared to the two.

I couldn't really find any clinical study about Fladrafinil and the information about it is very limited as of right now. Most of the information we have available is anecdotes.

Fladrafinil is more intense wakefulness and alertness promoting Smart Drug than Modafinil and Adrafinil with limited studies about it available (most information we have are anecdotes).

Flmodafinil Overview

Flmodafinil is found under 4 different names;

  • CRL-40,940
  • Flmodafinil
  • Bisfluoromodafinil
  • Lauflumide (NLS-4)

It is the bisfluoro analog of Modafinil. An analog just basically means that the compound has a similar chemical structure to Modafinil with a few differences.

Like Fladrafinil, Flmodafinil (crl 40,940) is also a potent eugeroic as well as a dopamine reuptake inhibitor.

Most people taking Flmodafinil report that it is more potent than Modafinil (up to 30% stronger and higher bioavailability) which is backed up by a few clinical studies.

Flmodafinil works by increasing the levels of histamine in the hypothalamus.

Histamine is a neurotransmitter that is associated with wakefulness and Flmodafinil increases its production.

Again, I couldn't find any good clinical study about Flmodafinil but there are quite a few studies about Modafinil so we can make some assumptions.

Here is what one study concluded:

"In summary, NLS-4 is a potent stimulant with different effects than its parent compound modafinil (Rambert et al., 1986) and most other stimulants in terms of potency and effects on sleep rebound and the sleep EEG."

You can find the study here.

It's worth noting that it was only recently patented (2013) and clinical trials have been underway since 2015. It is currently in Phase 1.

If you want to buy flmodafinil it's important to make sure that it is pure and not contaminated with any other drugs which can happen a lot for people who purchase flmodafinil.

That's why it's important to check your flmodafinil powder or capsules to see if it's pure or not.

Also, check the legality of flmodafinil. Is Flmodafinil legal in your country or not?

Flmodafinil (crl 40,940) is a powerful eugeroic - wakefulness and alertness promoting Smart Drug. It is an analog to Modafinil which means that it is similar in structure. Flmodafinil is considered to be stronger than Modafinil with promising results in clinical trials. You can buy flmodafinil online at most vendors.

So What's The Difference?

As I briefly mentioned in the beginning, the data available on both drugs is relatively limited.

That being said, we know that both Fladrafinil and Flmodafinil are powerful eugeroics that mimic the effects of Adrafinil and Modafinil.

Since they are both analogs to Modafinil and Adrafinil they work just the same in terms of wakefulness and alertness.

This means that they both have similar neuropsychopharmacological properties.

The only difference between Fladrafinil and Flmodafinil powder from the studies I could find are the side effects and potency.

Fladrafinil seems to have more severe side effects when compared to both Adrafinil and Flmodafinil which is why most people shy away from it.

Although some people say that Flmodafinil (crl 40,940) is one of those Smart Drugs that you either: "feel it working or not" (this guy on Reddit talks about it here).

In terms of Flmodafinil side effects there don't seem to be anything worth noting other than the common headache (usually a result of dehydration) and trouble sleeping if taken late in the day.

It is also thought to have a longer half-life as well. Some people see it as improved modafinil.

This means that it will stay in your system for longer and you may feel the effects for up to 16 hours.