Alpha Brain Review: Dosage, Benefits, Side Effects & Where to Buy Online (2024)

Updated June 11, 2024 by | Reviewed by William Gallagher, MNeuroSci
(Estimated reading time: 13 minutes)

Alpha BRAIN is a popular nootropic supplement that aims to enhance cognitive function, improve memory, and boost mental performance. Developed by Onnit Labs, and popularized by Joe Rogan, Alpha BRAIN has gained significant attention in the nootropic community. In this article, we will explore the key aspects of Alpha BRAIN, including its ingredients, claimed benefits, and the company behind the product.

What Is Alpha BRAIN and How Does It Claim to Enhance Cognitive Function?


Alpha BRAIN is a dietary supplement that combines various natural ingredients to support brain health and cognitive performance. The product is designed to help individuals achieve optimal mental clarity, focus, and memory retention.

What Are the Core Ingredients in Alpha BRAIN and What Roles Do They Play?

Alpha BRAIN contains a blend of ingredients, including Alpha-GPC, Huperzine A, Bacopa Monnieri, and L-Theanine. Alpha-GPC is a choline compound that may increase acetylcholine levels, promoting better focus and mental clarity. Huperzine A, which is known to improve cognitive function and memory. Bacopa Monnieri has been used traditionally to support memory and cognition, while L-Theanine is an amino acid that may promote relaxation and reduce stress.

IngredientDosage Per Serving (2 Capsules)
Vitamin B6 (as Pyridoxine HCl)10 mg (588% DV)
Onnit Flow Blend650 mg

L-TyrosineNot specified
L-TheanineNot specified
Oat (straw) ExtractNot specified
PhosphatidylserineNot specified
Cat's Claw (bark) Extract350 mg
Onnit Focus Blend240 mg
L-Alpha glycerylphosphorylcholine (Alpha GPC)Not specified
Bacopa (leaves) Extract100 mg
Huperzine A400 mcg
Onnit Fuel Blend60 mg
L-LeucineNot specified
PterostilbeneNot specified

How Do These Ingredients Affect Brain Health and Cognitive Abilities?

The ingredients in Alpha BRAIN work synergistically to support various aspects of brain health and cognitive function. By increasing neurotransmitter levels, such as acetylcholine, and promoting blood flow to the brain, these ingredients may enhance mental clarity, focus, and memory retention. Additionally, some components, like L-Theanine, may help reduce stress and anxiety, contributing to overall cognitive well-being.

Who Manufactures Alpha BRAIN and Can Their Reputation Be Trusted?

Alpha BRAIN is manufactured by Onnit Labs, a well-known company in the health and wellness industry. Founded by Aubrey Marcus in 2010, Onnit has gained a reputation for producing high-quality supplements and fitness equipment.

What Is the Company's Background and Its Impact on Alpha BRAIN's Credibility?

Onnit Labs focuses on providing products that support overall well-being and cognitive performance. The company's commitment to quality and transparency has contributed to Alpha BRAIN's credibility in the nootropic market. Onnit's collaboration with renowned figures like Joe Rogan has also helped raise awareness about Alpha BRAIN and its potential benefits.

Are There Clinical Studies or Research Validating Alpha BRAIN's Claims?

While Alpha BRAIN itself has not undergone extensive clinical trials, some of its individual ingredients have been studied for their cognitive-enhancing properties. Onnit conducted a small study involving 63 participants who took Alpha BRAIN for 6 weeks, reporting improvements in certain cognitive domains, although specific details were not provided. More research is needed to fully validate the effectiveness of Alpha BRAIN's specific formulation.[1]

What Are the Proclaimed Benefits of Using Alpha BRAIN? (Pros)

Alpha BRAIN is marketed as a supplement that can enhance various aspects of cognitive function. Some of the claimed benefits include improved focus and concentration, better memory retention and recall, increased mental clarity, and enhanced overall brain health. Users have reported positive experiences, citing increased productivity, better multitasking abilities, and improved verbal fluency.

How Effective Is Alpha BRAIN in Enhancing Memory, Focus, and Overall Cognitive Abilities?

Alpha BRAIN has shown promise in enhancing certain cognitive functions, particularly verbal memory and executive functioning, based on a randomized, double-blind, placebo-controlled study.[2] However, the study was funded by Onnit, the manufacturer of Alpha BRAIN, which may introduce potential bias. More independent research is needed to fully validate the efficacy of Alpha BRAIN's specific formulation.

What Are the Potential Side Effects or Risks Associated with Alpha BRAIN? (Cons)

While Alpha BRAIN is generally well-tolerated, some users have reported mild side effects such as headaches, nausea, insomnia, and gastrointestinal issues. The long-term safety and potential interactions of Alpha BRAIN's proprietary nootropic blend are not well-established, warranting caution and consultation with healthcare professionals before use.

What Are the Known Side Effects of Alpha BRAIN's Ingredients?

Some ingredients in Alpha BRAIN, such as Alpha-GPC, Huperzine A, and Bacopa Monnieri, have been associated with side effects like headaches, dizziness, nausea, and sleep disturbances in certain individuals. However, the prevalence and severity of these side effects in the context of Alpha BRAIN's specific formulation remain unclear due to the use of proprietary blends.

Does Alpha BRAIN Interact with Other Medications or Supplements?

Potential interactions between Alpha BRAIN and medications or other supplements are not well-documented. However, some ingredients like Huperzine A may interact with certain medications, such as blood thinners or anticonvulsants. It is crucial to consult a healthcare professional to assess potential interactions based on individual health status and medication regimen.

My Honest Personal Experience and Evaluation of Alpha BRAIN

During my 12-week trial of Alpha BRAIN, I noticed several positive effects on my cognitive function. I experienced improved mental clarity, which allowed me to think more clearly and efficiently. My focus and concentration also seemed to be enhanced, enabling me to stay on task for longer periods without getting distracted. Additionally, I noticed an improvement in my verbal fluency, finding it easier to articulate my thoughts and engage in conversations. Lastly, I felt an increase in motivation, which helped me tackle tasks and projects with greater enthusiasm.

What Were My Initial Impressions and Expectations of Alpha BRAIN?

Initially, I was intrigued by the popularity of Alpha BRAIN and its endorsement by high-profile figures like Joe Rogan. The product's marketing claims of enhanced cognitive function, improved memory, and increased focus set high expectations. However, upon further research into the ingredients and available scientific evidence, I approached the trial with a more cautious and critical perspective, recognizing the need for more robust, independent studies to substantiate the claims.

How Did I Incorporate Alpha Brain into My Daily Routine and Lifestyle?

I took the recommended dose of two Alpha Brain capsules each morning with breakfast. On days when I had mentally demanding tasks or needed extra focus, I occasionally took an additional capsule in the afternoon. I maintained this routine consistently for the duration of my 12-week trial.

What Immediate and Long-Term Effects Did I Observe?

In the first week, I noticed a subtle increase in mental clarity and focus. Over the following weeks, I experienced improved verbal fluency, enhanced memory recall, and a greater capacity to handle complex cognitive tasks. These effects seemed to plateau around the 8-week mark and remained steady until the end of my trial.

Did I Experience Any Side Effects or Adverse Reactions?

Throughout my 12-week use of Alpha Brain, I did not encounter any significant side effects. Occasionally, I experienced mild headaches and a slight increase in vivid dreams, but these were infrequent and did not disrupt my daily functioning or sleep quality.

How Does My Experience Align with Alpha Brain's Claims and User Testimonials?

My personal experience with Alpha Brain largely aligns with the product's claims of enhanced focus, memory, and overall cognitive performance. The improvements I noticed in verbal fluency and motivation are also consistent with the experiences shared by many other Alpha Brain users in their testimonials.

How Do Real Users Rate Alpha Brain's Impact on Cognitive Performance?

Based on Reddit user reviews, opinions on Alpha Brain's effectiveness for cognitive enhancement are mixed. Some users report positive experiences, noting improvements in focus, mental clarity, and verbal fluency. Others find the effects to be subtle or attribute any perceived benefits to placebo. Several users mention that while Alpha Brain may provide a slight cognitive edge, it is not a drastic or transformative solution.

What Common Experiences Are Shared in Customer Testimonials?

Reddit users report increased focus, improved memory recall, and enhanced mental clarity while taking Alpha BRAIN. According to Alpha BRAIN's official website, some customers also mention experiencing a boost in verbal fluency and a greater sense of motivation. While individual results vary, the majority of user testimonials indicate positive experiences with Alpha Brain's impact on cognitive performance.

How Consistent Are User Experiences with Alpha Brain's Advertised Claims?

User experiences with Alpha Brain vary, with some reporting improved focus, memory, and mental clarity, while others notice minimal or no effects. The inconsistency in user testimonials suggests that individual responses to Alpha Brain may differ, and the supplement's efficacy may not be universal.

What Is the Recommended Usage of Alpha Brain for Optimal Cognitive Benefits

To potentially enhance the effects of Alpha Brain, users should consider incorporating it into a healthy lifestyle that includes regular exercise, a balanced diet, and sufficient sleep. It's important to note that the effects of Alpha Brain may not be immediately noticeable, as some ingredients like Bacopa Monnieri and Phosphatidylserine may require consistent use over several weeks to produce cognitive benefits. Users should not expect Alpha Brain to work like a "magic pill" that instantly boosts cognitive performance, but rather as a supplement that supports brain health and function over time.

What Dosage, Frequency, and Timing Are Recommended?

The recommended dosage for Alpha Brain is typically two capsules per day, preferably taken in the morning or early afternoon. However, some users may find that adjusting the dosage based on their individual needs and tolerance leads to better results.

Are There Any Best Practices or Guidelines for Enhancing Its Effects?

To potentially enhance the effects of Alpha Brain, users may consider combining it with a healthy lifestyle, including regular exercise, a balanced diet, and sufficient sleep. Consulting with a healthcare professional before starting any new supplement regimen is always advised.

What Does Scientific Research Say About Alpha Brain's Ingredients and Efficacy?

Several key ingredients in Alpha Brain, such as Bacopa monnieri, L-theanine, and phosphatidylserine, have been studied for their potential cognitive benefits. A meta-analysis of randomized controlled trials found that Bacopa monnieri extract can improve cognitive performance, particularly in the domains of attention and memory.[3] L-theanine, when combined with caffeine, has been shown to enhance cognitive performance and increase subjective alertness.[4] Phosphatidylserine (PS), a phospholipid found in high concentrations in the brain, plays a crucial role in neuronal function and has been associated with improved cognitive performance in various studies.[5]

Is There a Consensus in the Scientific Community on Alpha Brain's Effectiveness?

While there is no strong consensus in the scientific community regarding Alpha Brain's effectiveness, Onnit does provide some insight into the product's efficacy. The website mentions a randomized, double-blind, placebo-controlled study that showed improvements in verbal memory and executive function in healthy adults who took Alpha Brain. However, it is important to note that this study was sponsored by Onnit, and independent replication of these findings would strengthen the evidence for Alpha Brain's effectiveness.

How Does Alpha Brain Compare to Other Nootropics in the Market?

The premium price point and carefully crafted blend of high-quality ingredients distinguish Alpha Brain from many other nootropic supplements on the market. However, the limited scientific evidence specific to Alpha Brain still makes it challenging to definitively compare its effectiveness to other well-researched nootropics, and ultimately, the best nootropic for an individual will depend on their specific cognitive needs, preferences, and response to different formulations.

What Unique Features or Ingredients Distinguish Alpha Brain?

Alpha Brain contains unique ingredients like Cat's Claw Extract (AC-11) and Oat Straw Extract, which are not commonly found in other nootropic supplements. However, the use of proprietary blends makes it difficult to determine the exact doses of these ingredients and assess their effectiveness.

Are There Competing Products That Offer Better Results or Value?

Competitors like NooCube and Mind Lab Pro offer similar ingredients to Alpha Brain but with more transparent dosing and potentially better value for money. These products also contain additional clinically-proven nootropic ingredients that Alpha Brain lacks.

What Are the Limitations or Criticisms of Alpha Brain?

One of the main criticisms of Alpha Brain is the limited scientific evidence specifically evaluating Alpha Brain's formulation. While some of its ingredients have been studied individually, more research is needed to establish the efficacy and safety of the specific blend used in Alpha Brain.

Another criticism is the lack of transparency when it comes to the exact dosage of each ingredient used in Alpha Brain. While the supplement facts label provides the amounts for the Onnit Flow Blend and Onnit Focus Blend, it does not specify the individual dosages for each of the ingredients within those proprietary blends, making it difficult for consumers to fully understand the composition and potency of the product.

Are There Any Drug Interactions or Contraindications?

Some ingredients in Alpha Brain, such as Huperzine A, may interact with certain medications like blood thinners and anticonvulsants. It is crucial to consult a healthcare professional before using Alpha Brain, especially if you have pre-existing medical conditions or are taking other supplements or medications.

What Ethical Considerations Surround the Use of Alpha Brain?

The use of nootropics like Alpha Brain raises ethical questions about the enhancement of cognitive abilities and the potential for creating unfair advantages. There are also concerns about the long-term safety and potential side effects of these supplements, particularly when used by healthy individuals without medical supervision.

How Does Alpha Brain's Pricing Compare to Similar Products?

Alpha Brain is priced at a premium compared to many other nootropic supplements on the market. While it contains some unique ingredients the limited scientific evidence for its specific formulation may not justify the higher cost for some consumers.

Does Alpha Brain Offer Financial Incentives Like Discounts or a Money-Back Guarantee?

Alpha Brain offers a 90-day money-back guarantee, allowing customers to try the product risk-free and request a full refund if they are not satisfied with the results. Onnit, the company behind Alpha Brain, also provides occasional discounts and promotions, such as subscription savings and bundle deals, which can make the product more affordable for regular users. However, these incentives may vary over time and are subject to change.

What Are Common Consumer Concerns and Questions About Alpha Brain?

Common consumer concerns and questions about Alpha Brain include the safety and potential side effects of the supplement, especially when used long-term or in combination with other medications. Some users may also inquire about the effectiveness of the product, given the limited scientific evidence specifically evaluating Alpha Brain's formulation. Additionally, consumers may have questions about the proper dosage, timing, and duration of use for optimal results.

What Are the Guidelines for Combining Alpha Brain with Other Supplements?

When combining Alpha Brain with other supplements, it is essential to be aware of potential interactions and to consult with a healthcare professional to ensure safety. Some ingredients in Alpha Brain, such as Huperzine A, may interact with certain medications or have synergistic effects with other nootropics, which could lead to adverse reactions. It is generally recommended to start with a lower dose when combining supplements and to monitor for any negative side effects.

Who Should Avoid Using Alpha Brain and Why?

Individuals with pre-existing medical conditions, especially those related to the brain or cardiovascular system, should consult with a healthcare professional before using Alpha Brain. Pregnant and nursing women should also avoid using this supplement due to the lack of safety data in these populations. Additionally, people taking medications that may interact with Alpha Brain's ingredients, such as blood thinners or anticonvulsants, should exercise caution and seek medical advice before use.

Where Can Alpha Brain Be Purchased?

Alpha Brain can be purchased through various channels, including the official Onnit website and authorized retailers. It is essential to ensure the authenticity of the product when buying from third-party sellers to avoid counterfeit or expired products. Avoid Amazon, Walmart, and eBay.

What Are the Official Channels for Buying Alpha Brain?

The official Onnit website is the primary and most reliable channel for purchasing Alpha Brain. Buying directly from the manufacturer ensures product authenticity, access to customer support, and eligibility for the money-back guarantee.

Are There Authorized Retailers or Online Platforms for Alpha Brain?

In addition to the official Onnit website, Alpha Brain may be available through authorized retailers and online platforms such as GNC, and The Vitamin Shoppe. However, customers should verify the seller's legitimacy and check for authentic Onnit packaging and branding before making a purchase.

What Should Buyers Be Aware of When Purchasing Alpha Brain to Ensure Authenticity?

To ensure the authenticity of Alpha Brain, buyers should purchase the product from the official Onnit website or authorized retailers. They should look for genuine Onnit branding, packaging, and safety seals, and be cautious of extremely low prices or deals that seem too good to be true, as these may indicate counterfeit or expired products. If in doubt, buyers can contact Onnit customer support to verify the legitimacy of a seller or product.

Based on the Review, Is Alpha Brain Recommended for Cognitive Enhancement?

Based on the available scientific evidence, my personal experience, and user experiences, Alpha Brain offer some benefits for cognitive enhancement, particularly in the areas of memory, focus, and mental clarity. However, individual results may vary, and the long-term effects of the supplement are not well-established.

Frequently Asked Alpha Brain Questions (FAQ)

Is Alpha Brain Safe?

Alpha Brain is generally considered safe when taken as directed, but may cause mild side effects like headaches, nausea, or insomnia in some users. It contains a blend of natural ingredients like Alpha-GPC, Bacopa monnieri, and Huperzine A, which are well-tolerated by most people.

How Long Does Alpha Brain Last?

The effects of Alpha Brain typically last 4-6 hours after taking the recommended dose of 2 capsules. However, the duration can vary based on individual factors like metabolism, dosage, and tolerance.

Is Alpha Brain Legit (Does it Really Work)?

While some users report improved focus, memory, and cognitive function, the efficacy of Alpha Brain is not conclusively proven. Limited studies suggest potential benefits, but more research is needed to validate its claims as a nootropic supplement.

Is Alpha Brain FDA-Approved?

No, Alpha Brain is not FDA-approved as it is classified as a dietary supplement, not a drug. The FDA does not approve dietary supplements, but manufacturers must ensure their products are safe and accurately labeled.

Does Joe Rogan Take Alpha Brain?

Yes, Joe Rogan is a well-known advocate and user of Alpha Brain. He has been taking the supplement since its launch in 2011 and frequently promotes it on his podcast, citing improved verbal fluency and focus as benefits.

Does Alpha Brain help reduce anxiety?

While Alpha Brain contains some ingredients like L-theanine that may promote relaxation, there is limited evidence that it significantly reduces clinical anxiety levels.

Can Alpha Brain be used to treat ADHD symptoms?

No, Alpha Brain is not an approved treatment for ADHD. However, some users report improvements in focus and concentration.

Is it safe to take Alpha Brain if drinking alcohol?

Mixing Alpha Brain and alcohol is generally not recommended, as the effects and potential interactions are not well-studied.

What is Alpha Brain Black Label?

Alpha Brain Black Label is a premium version that contains additional ingredients like lion's mane mushroom for enhanced cognitive support.

Will Alpha Brain cause a false positive on a drug test?

There are no confirmed reports of Alpha Brain triggering false positives, but its proprietary blends make interactions difficult to predict.

Does Alpha Brain provide an energy boost?

Alpha Brain is not a traditional energy supplement, but some users report increased mental energy and alertness.

How long is the shelf life of Alpha Brain?

Most Alpha Brain products have a 2-year shelf life from the manufacturing date when stored properly.

Is Alpha Brain effective for women?

Yes, the ingredients in Alpha Brain can support cognitive function in both men and women.

Can Alpha Brain enhance gaming performance?

Some gamers report improved focus and reaction times when using Alpha Brain, though individual results may vary.

Can Alpha Brain be used as a pre-workout supplement?

While not marketed as such, some users take Alpha Brain before workouts for increased mental energy and focus.

  1. Solomon, Todd M et al. “A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally.” Human psychopharmacology vol. 31,2 (2016): 135-43. doi:10.1002/hup.2520 â†‘
  2. Solomon, Todd M et al. “A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally.” Journal of the International Society of Sports Nutrition vol. 12,Suppl 1 P54. 21 Sep. 2015, doi:10.1186/1550-2783-12-S1-P54 â†‘
  3. Kongkeaw, Chuenjid et al. “Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.” Journal of ethnopharmacology vol. 151,1 (2014): 528-35. doi:10.1016/j.jep.2013.11.008 â†‘
  4. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513 â†‘
  5. Kim, Hee-Yong et al. “Phosphatidylserine in the brain: metabolism and function.” Progress in lipid research vol. 56 (2014): 1-18. doi:10.1016/j.plipres.2014.06.002 â†‘