Emoxypine Succinate is used as an Anxiolytic and is similar to pyridoxine which is Vitamin B6. Studies show that Emoxypine is effective in normalizing the sleep-wake-cycle and promoting enhanched cognitive function with low side-effects.
So recently I came across a rather interesting Nootropic called; Emoxypine Succinate, or Mexidol, on Reddit.
If you’re doing some research on Emoxypine Succinate you will quickly notice how difficult it is to find some information about it.
Initially what I found was a Wikipedia page, some anecdotes from Reddit and a couple of sentences on a product page on NootropicsDepot and Science.bio.
I then tried to look up Emoxypine on PubMed and found A LOT of interesting studies that I want to share with you guys.
I will try to combine the more general information about the Nootropic, what the science say and share the personal experiences from people on Reddit.
My hope is that this article will act as a general source for all things Emoxypine and give you some more information about this Nootropic before you buy.
Here’s what we will be covering today:
- What is Emoxypine Succinate?
- How does it work?
- What are the benefits and side effects?
- How much should you take?
- What other Reddit users are saying about Emoxypine
So without further ado, let’s just jump straight into it.
Read Also: My Top 3 Favourite Nootropics Of All Time
What Is Emoxypine Succinate?
As briefly mentioned in the beginning of this article, Emoxypine is an Anxiolytic when used as the succinate salt.
It has similar structure as pyridoxine which is a type of Vitamin B6.
Vitamin B6 occurs naturally in the foods we eat and helps the production of red blood cells, and proper functioning of nerve impulses.
From what I could find Emoxypine was first synthesized in Russia by a company called, PharmaSoft.
Though it isn’t approved for any particular medical use in EU and the US, it is widely used in Russia.
According to this study we can see that it shows promising results as an Anxiolytic.
For those of you who don’t know what an Anxiolytic is, it’s basically just a Nootropic/medication that reduces anxiety.
From the study we can also see that the scientists observed an antidepressant effect as well as neuroprotective and anti-inflammatory action.
Other studies suggest that Emoxypine may improve blood circulation in the brain as well as being cardioprotective.
With that said, there are two main forms of Emoxypine.
The A form is the succinate salt and the B form is the hydrochloride salt.
The difference between the two is that the B form has a better solubility in water allowing more bioavailability when taken by mouth. This may allow for quicker onset as well as longer half-life.
What is the half-life for Emoxypine?
The half-life of Emoxypine as a blood plasma level is approximately 4 days.
Because it’s a slow release drug, it may have longer half-life in the body than with some of the other more fast acting nootropics.
The main concern for Emoxypine is the blood plasma level.
When taken orally (the succinate salt form) it has a rapid onset and short half-life at around 30 min, but some results show that it has prolonged half-life of 5h and 7.5h when dosed in dogs.
To put things into perspective, most nootropics have a half-life of around 1 hour.
This is because the majority of them are water soluble and their primary mode of release into the blood plasma is through oral ingestion.
Because Emoxypine is water soluble it has a longer half-life than most of the other nootropics. This fact makes it a much more interesting option for those who want to use it in a medical setting.
It would allow for examination and measurement of the blood plasma levels of the compound at any given time so that you can see how it affects the individual.
This also means that people using Emoxypine wouldn’t have to worry about over-dosing or side effects from the drug because they can determine their blood plasma levels at any time.
For this reason I’d say Emoxypine is an extremely interesting compound.
How Does Emoxypine Work?
There is a general consensus that Emoxypine’s mechanism of action is believed to be its antioxidant and neuroprotective abilities.
The information we have about Emoxypine is very limited.
That being said, I found a list on PubMed & Wikipedia briefly talking about the advantages, how and why it works.
This is what I could find:
- Emoxypine inhibits free radicals and increases antioxidant enzymes (has neuroprotective effects)
- It blocks the formation of leukotrienes which are inflammatory mediators (has anti-inflammatory effects)
- It modulates/enhances GABA and acetylcholine receptors in the brain (has Anxiolytic effects)
Emoxypine has also shown to improve cognitive function in patients with Alzheimer’s disease as well as shown to improve memory in patients with Parkinson’s disease.
The fact that Emoxypine has been shown to have antioxidant, anti-inflammatory and neuroprotective properties suggests that it prevents cell death by increasing the production of choline within the body.
This, along with its other benefits, is why Emoxypine is believed to be beneficial for patients suffering from Alzheimer’s disease as well as other types of dementia and age-related memory loss.
The mechanism of this is believed to be its antioxidant and neuroprotective abilities.
Antioxidants are compounds that may prevent damage to your body and provide repair to cells. Basically, they help to defend your body and keep it from getting sick (cell Death).
Neuroprotective Agents (like Emoxypine) are thought to help protect your brain from physical injury and mental stress. Neuroprotective agents may be of benefit in situations where brain cells are particularly vulnerable, such as in stroke and head injury. This area is still being researched though.
What Are The Benefits & Side Effects?
As briefly mentioned above Emoxypine seems to be very effective when it comes to certain type of conditions.
These conditions are:
- Neurodegenerative diseases
Since Emoxypine inhibits free radicals in the brain it would make sense why it is seen as neuroprotective. As you might know, free radicals can have a harmful effect on our brains leading to oxidative stress.
In the studies I linked to previously we can also see how effective Emoxypine was on the participants, normalizing their behaviour following stressful events.
“The most pronounced anxiolytic action was observed upon the administration of emoxypine.”
Interesting enough I haven’t been able to find any studies that report about any negative outcomes/side-effects.
Emoxypine also seems to have Anti-inflammatory effects by blocking leukotrienes from forming.
This study demonstrates the efficiency and how it diminishes the magnitude of a systemic response as well as how the Nootropic has an organ-protective effect.
So to summarize the potential advantages you may experience, here’s a list:
- You may experience less anxiety (especially social anxiety)
- You may experience less depression
- You may experience less stress
- In turn, you may experience better focus
- You may experience better memory & creativity
In terms of side-effects I couldn’t really find anything worth mentioning other than most people on Reddit seem to avoid taking it on training days.
The reason behind this is because Emoxypine is an antioxidant.
Antioxidants can have a negative effect on muscle gains.
What’s The Right Dosage?
As is the case with all Nootropics, dosages really depends on your personal goals, body weight and tolerance.
From what I could find on Reddit people take anywhere from 50mg to 2grams.
2 grams seems to be pretty over the top if you ask me. I always recommend taking a smaller dose in the beginning and then gradually work your way up.
Even though Emoxypine is well tolerated for most people with no side effects it’s always better to be careful when first starting out.
If you’re buying Emoxypine from Science.bio you can either buy it in powder form or capsules.
The Emoxypine Succinate Powder comes in 10 and 30 grams. As for the capsules, you can get 60 or 120pills. One pill is 125mg.
The only downside to NootropicsDepot is how little information they have about their products, especially when it comes to dosages.
As a rule of thumb I always start out with the lowest dose possible which in this case is 125mg (1 capsule).
What Reddit Users Are Saying About Emoxypine
The first thread about Emoxypine on Reddit that I found is about its positive effects.
A Reddit user called; u/Hormesis is talking about how underrated it is. He starts out by saying how he tries to avoid posting subjective reports about Nootropics. He goes on to state that he has to break is own rule by saying the following:
“Emoxypine is a fantastic, seemingly underrated substance.”
Hormesis notices the great anxiolytic effect he gets as well as the lack of impairment and complete absence of hangovers.
Hormesis is consuming 200mg of Emoxypine every second day stating that the only reason why he is not taking it daily is because it’s an antioxidant (high levels of antioxidants can have a diminishing effect on muscle gains – he works out).
Another user called; u/tylrdbmr talks about how wonderful Emoxypine is. He starts off by asking why there isn’t more appreciation for it.
He then goes on to say that it’s his favorite Nootropic, initially trying it out after hearing about its anti-alchohol effects.
Tylrdbmr is then speaking highly of the effects it has on his mental clarity, anxiety and socialbility.
He also briefly talks about how he’s yet to run into any negative side effects after 1 year of use and research.
The only concern he has is the potential impact on muscle growth which u/Hormesis also talked about briefly.
Another user called; u/blase-prude is talking about Emoxypine benefits and stacks. He starts off by saying:
“Emoxypine is great for it’s subtle improvements to cognition and it’s ability to help me through anxiety.”
u/blase-prude is a long-term user of Emoxypine. What he has noticed is how the Nootropic has resulted in an overall gain in happiness.
He also states that it is easier to get up in the morning and how he’s more productive in the mornings:
“I wake up without fear of the day…”
He then goes on to say how it is the most underrated Nootropic he has used.
He stacks Emoxypine with;
He gets better results stacking Emoxypine, but on its own he notices subtle effects as well.
He finishes off by encouraging people to try it out.
Especially beginners that don’t want to use the more synthetic Nootropics and want to try something that is well-tolerated.
Emoxypine is a unique Nootropic that seems to have very positive effects on the body as well as the brain.
It seems to have more benefits than any other Nootropic I’ve used, including Piracetam and Aniracetam.
We can see from these Reddit posts that it’s heavily under-appreciated. It is definitely worth trying if you’re looking for something new and different, especially beginners.
Have you tried Emoxypine? What was your experience like? Shoot me a message and let me know 🙂
That’s it. I hope this article has been beneficial for you. If you’re curious to know more about Emoxypine, or just want to check the current market price on this popular Smart Drug, then you can find more information about it right here.
- https://pubmed.ncbi.nlm.nih.gov/12109287/ (“Effect of mexidol, emoxypine, and dimephosphon on electrophysiological effects of nibentan”)
- https://pubmed.ncbi.nlm.nih.gov/22379875/ (“Efficacy of emoxipine and mexidol in patients with chronic disorders of the digestive system and atherosclerosis of the abdominal aorta”)
- https://pubmed.ncbi.nlm.nih.gov/12227086/ (“Effect of emoxypine on myocardial electrical instability and homeostasis parameters in patients with acute disturbance of cerebrovascular circulation”)
- https://pubmed.ncbi.nlm.nih.gov/28638031/ (“Anxiolytic and antidepressant effects of emoxipine, reamberin and mexidol in experimental diabetes mellitus”).
What is Emoxypine good for?
Emoxypine is said to improve cerebral blood circulation, inhibit thrombocyte aggregation, lower cholesterol levels and have cardioprotective and antiatherosclerotic action.
How do you take Mexidol?
Take MEXIDOL as follows:
- 500 mg / day for 10 days followed by 1 tablet of 125 mg 3 times a day (daily dose 375 mg) for 8 weeks.
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