8 Best Nootropics To Stack With Adderall In 2024

Updated May 4, 2024 by | Reviewed by William Gallagher, MNeuroSci
(Estimated reading time: 12 minutes)

I'll examine the 8 best nootropics to stack with Adderall in this article. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.

If you're currently taking Adderall and looking to increase its effects, whether it be for increased focus or better productivity, stacking nootropics with your regimen can help you achieve the desired results.

Adderall is one of those drugs that has a plethora of uses, from treating ADHD all the way to helping people with narcolepsy stay awake. It's also become increasingly popular as an off-label performance enhancer for those who want to get an edge on their work or studies. This is why it's important to understand how stacking nootropics can help you increase the effects of Adderall.

Here, I'll give you an overview of some of the most popular nootropics to stack with Adderall, including their potential risks and side effects.

So without further ado, let's dive in, shall we?

The best nootropics to stack with Adderall, according to scientific evidence, are:

  • Nooceptin
  • CDP Choline
  • Alpha GPC
  • L-Theanine
  • Piracetam
  • Phenibut
  • Creatine
  • Ashwagandha

1. Nooceptin

Nooceptin is a nootropic blend. Nootropic blends combine nootropic ingredients to improve their benefits. This means that they work synergistically to amplify the effects of each ingredient. Nooceptin supports cognitive productivity and enhances energy levels when taken with Adderall.

It also has some anti-anxiety properties, which can be beneficial in reducing stress levels while taking stimulants like Adderall.

The Nooceptin ingredients are:

  • Citicoline 200 mg
  • Rhodiola Rosea Extract 150 mg
  • Bacopa Monnieri Extract 150 mg
  • L-Theanine 200 mg
  • Ginkgo Biloba Extract 100 mg
  • Lion's Mane Extract 400 mg
  • Panax Ginseng Extract 200 mg

Numerous pre-clinical and clinical studies have revealed that Lion's Mane Mushroom effectively relieves symptoms of depression through its monoaminergic modulation, neurogenic/neurotrophic, and anti-inflammatory pathways.[1]

This suggests the potential application of Lion's Mane Mushroom as an alternative medicine to treat depression safely yet effectively. This also makes it interesting as a part of an Adderall stack since it could help reduce some side effects, such as depression, associated with long-term Adderall use.

Nooceptin Pros

  • It can reduce some side effects of Adderall, such as depression, anxiety, and fatigue
  • It can increase focus and productivity when used with Adderall
  • Contains natural ingredients with multiple benefits
  • All-natural ingredients that work synergistically to enhance the effects of Adderall

Nooceptin Cons

  • Not ideal for people on a tight budget

Nooceptin in Summary

Nooceptin combines 7 all-natural nootropic ingredients into one powerful formula. It’s designed to increase focus and productivity when taken with Adderall and reduce some of the side effects associated with long-term use.

While it’s not ideal for those on a tight budget, its natural ingredients can pay off in terms of improved health and cognitive performance in the long run.

2. CDP Choline

CDP Choline, also known as citicoline, is a cognitive enhancer that’s been used to treat age-related memory decline, improve attention and focus, increase mental energy, and enhance overall brain health.

It works by increasing dopamine and acetylcholine (ACh) availability in the brain. This helps to improve focus, concentration, and mental clarity. Acetylcholine is also important for forming and strengthening neural connections, which can help with learning and memory formation.[2]

Choline is an essential nutrient used by your body to produce ACh. However, most people don’t get enough choline in their diet, so taking a supplement like CDP Choline can be beneficial.

Harsh stimulants like Adderall can deplete levels of dopamine and ACh, which is why adding CDP Choline to your stack can be helpful. It can also help reduce some side effects of long-term use, such as brain fog, headaches, and fatigue.

CDP Choline Pros

  • Increases focus and concentration when taken with Adderall
  • Improves learning and memory formation
  • Reduces some side effects such as brain fog, headaches, and fatigue

CDP Choline Cons

  • Not as effective for people already getting enough choline in their diet

CDP Choline in Summary

CDP Choline is an all-natural cognitive enhancer that has been scientifically proven to improve focus, concentration, and mental clarity. It works by increasing the availability of both dopamine and acetylcholine in the brain, which helps to boost overall cognitive function.

It can also help reduce some side effects associated with long-term stimulants like Adderall. However, it may not be as effective for people already getting enough choline in their diet.

3. Alpha GPC

Alpha GPC is another type of choline supplement known to increase acetylcholine levels in the brain. Alpha GPC helps to boost the effects of Adderall by increasing its ability to cross the blood-brain barrier (BBB), allowing more of the drug to reach the brain.

Alpha GPC provides an additional source of choline, an essential nutrient that plays an important role in neurotransmission. When combined with Adderall, Alpha GPC can help to reduce side effects such as anxiety and irritability while still providing the desired cognitive benefits.

Alpha-GPC is the clear winner when measured against CDP in clinical trials: it has been found to have superior results and increased patient satisfaction.[3]

Additionally, its greater absorption rate means it can be more successful at raising acetylcholine levels in the brain - giving users even better outcomes.

Alpha GPC Pros

  • Higher bioavailability than CDP Choline
  • Improves focus, concentration, and mental clarity
  • Reduces fatigue associated with stimulant use

Alpha GPC Cons

  • Alpha-GPC is a little more expensive than CDP Choline by milligram or serving

Alpha GPC in Summary

Alpha GPC is a powerful choline supplement that has been scientifically proven to improve focus and concentration when stacked with Adderall. It works by increasing acetylcholine levels in the brain, which can help reduce fatigue associated with stimulant use and improve overall cognitive function.

It is slightly more expensive than CDP Choline, but it has been shown to have superior bioavailability and greater patient satisfaction in clinical trials. Ultimately, Alpha GPC is an excellent nootropic to stack with Adderall if you’re looking for maximum results.

4. L-Theanine

L-Theanine is an amino acid found naturally in green tea that has been shown to reduce stress and anxiety while improving cognitive performance.

It works by increasing serotonin, dopamine, and GABA levels in the brain, which helps promote relaxation without causing drowsiness. Additionally, it has been shown to increase alpha brain waves associated with relaxation and improved focus.[4]

When stacked with Adderall, L-Theanine can help reduce the side effects such as jitteriness or insomnia while still providing the benefits of increased focus and concentration.

It also helps prevent tolerance building up, which can occur when taking stimulants like Adderall for long periods of time.

The recommended dosage for this stack is 200 mg of L-Theanine, taken once or twice daily along with your regular dose of Adderall.

L-Theanine Pros

  • Reduces stress and anxiety
  • Improves focus and concentration
  • Prevents tolerance buildup

L-Theanine Cons

  • Can cause drowsiness in high dosages

L-Theanine in Summary

Naturally found in green tea, L-Theanine is an amino acid that has been proven to reduce stress and anxiety while improving cognitive performance. When stacked with Adderall, it can help reduce side effects such as jitteriness or insomnia while still providing the benefits of increased focus and concentration.

5. Piracetam

Piracetam is a nootropic drug used to improve cognitive function and memory. It belongs to the racetam family of nootropics and works by increasing blood flow and oxygen consumption in the brain.[5]

Stacking Adderall and Piracetam can provide a synergistic effect, improving cognitive performance and memory retention:

  • Adderall increases levels of dopamine and norepinephrine in the brain, which can help improve focus and concentration.
  • Piracetam increases blood flow and oxygen consumption in the brain, which can help boost memory and cognitive function.

When these two nootropics are stacked together, they can work together to reduce side effects such as anxiety, agitation, irritability, or insomnia caused by Adderall while still providing the benefits of increased focus and concentration.

Additionally, Piracetam has a neuroprotective effect, helping to prevent damage to brain cells caused by oxidative stress.

Piracetam Pros

  • Improves cognitive performance and memory
  • Reduces Adderall-related side effects
  • Neuroprotective effect

Piracetam Cons

  • Hard to find high-quality Piracetam online

Piracetam in Summary

Piracetam is a powerful nootropic that can be stacked with Adderall to improve cognitive performance and memory. It works by increasing blood flow and oxygen consumption in the brain, which helps boost overall brain function. Additionally, it has been shown to reduce Adderall-related side effects such as anxiety, irritability, or insomnia while still providing the benefits of increased focus and concentration.

6. Phenibut

Phenibut is a tranquilizer sometimes used to reduce anxiety and improve sleep. There has been some discussion about combining the two, but there are potential risks associated with this combination.[6]

Phenibut is a derivative of the neurotransmitter GABA, which helps regulate mood and emotions. When combined with Adderall, it can increase the effects of both drugs.

This can lead to increased alertness, improved focus, and reduced anxiety. However, it can also increase the risk of side effects such as agitation, insomnia, headaches, and nausea.

Additionally, combining these two substances can lead to tolerance and dependence on both drugs over time. It's important to remember that mixing any two substances carries potential risks and should not be done without consulting a doctor or medical professional.

They will be able to assess your individual situation and advise you on the best course of action for your particular needs.

Phenibut Pros

  • Powerful anxiolytic effects
  • Can help reduce stress
  • Improves cognitive performance and sleep quality

Phenibut Cons

  • Can cause withdrawal symptoms
  • Can lead to tolerance and dependence

Phenibut in Summary

Phenibut is a powerful anxiolytic and nootropic that can help improve cognitive performance, reduce stress, and improve sleep quality when used correctly. Combined with Adderall, it can increase the effects of both drugs while potentially reducing some of the side effects associated with Adderall.

7. Creatine

Creatine is an amino acid located mostly in your body's muscles and the brain. It helps muscles produce energy (ATP) during heavy lifting or high-intensity exercise.

It has been found to be effective in maintaining muscular performance during the initial phase of high-volume exercise. Creatine supplementation has also been shown to increase the concentration of creatine within the muscles.[7]

Stacking creatine with Adderall can benefit those looking to improve their athletic performance and cognitive functioning. Adderall increases focus and alertness, while creatine provides a burst of energy when ATP stores have been depleted.

Together, they can help athletes push harder and longer during workouts and provide improved mental clarity and focus for tasks that require intense concentration.

Creatine Pros

  • Robust research supports creatine’s benefits
  • Readily available all over the world
  • Increases ATP production in the body
  • Improves mental clarity and focus
  • Reduces fatigue during exercise

Creatine Cons

  • Not ideal for people with kidney issues

Creatine in Summary

Creatine is an amino acid found naturally in the body that can help improve performance during exercise. It has been found to be effective at maintaining muscular performance and increasing creatine concentrations within muscle cells.

Stacking creatine with Adderall can improve mental clarity, focus, and energy for tasks requiring intense concentration or physical effort.

8. Ashwagandha

Ashwagandha, also known as Withania somnifera, is an evergreen shrub native to India and North Africa. It has been used in traditional Ayurvedic medicine for centuries to treat various ailments.

In recent years, scientific research has revealed that Ashwagandha can benefit many conditions, including stress relief and improved cognitive function.

When it comes to stacking Ashwagandha with Adderall, the combination can benefit those looking to improve their focus and concentration. Ashwagandha helps reduce stress levels, which can help reduce the side effects of Adderall, such as anxiety and irritability.

Additionally, Ashwagandha has been shown to improve memory formation, sleep quality, and recall, which can help enhance the effects of Adderall on cognition.[8]

Finally, Ashwagandha can also help reduce fatigue associated with Adderall use.

Ashwagandha Pros

  • Reduces stress levels
  • Improves memory formation, recall, and sleep quality
  • Enhances the effects of Adderall on cognition
  • Reduces fatigue associated with Adderall use

Ashwagandha Cons

  • It can take a while to start working

Ashwagandha in Summary

Ashwagandha is a beneficial nootropic that can help reduce stress levels and improve cognitive functioning when combined with Adderall. It provides a natural alternative to the side effects of Adderall, such as anxiety and irritability. It's an adaptogen that helps to reduce fatigue and improve sleep quality, which can further enhance the effects of Adderall.

What Are the Best Nootropics To Stack With Adderall?

best nootropics to stack with adderall

According to my market research and the available literature, the 8 best nootropics to stack with Adderall in 2023 are:

  • Nooceptin
  • CDP Choline
  • Alpha GPC
  • L-Theanine
  • Piracetam
  • Phenibut
  • Creatine
  • Ashwagandha

If you're looking to stack with Adderall and improve your focus, mental clarity, concentration, and emotional well-being, these are the nootropics you should consider.

It's worth pointing out that my list contains a mixture of natural and synthetic nootropics, so if you don't want to deal with the potential side effects of the synthetics, then opt for a natural option.

How to Choose the Right Nootropic Supplement To Stack With Adderall?

The first step in choosing the right nootropic supplement to stack with Adderall is determining your goals.

Do you want to improve focus, memory, creativity, or something else?

Once you have identified your goals, you can research which nootropics may best suit them. For example, Alpha GPC and/or Piracetam can be beneficial if you want to improve focus and productivity.

It’s also important to consider the side effects of each nootropic supplement before stacking it with Adderall. Some supplements may interact negatively with Adderall or cause unwanted side effects when taken together.

Therefore, it’s essential that you speak with your doctor before combining any supplements with prescription medications like Adderall.

Also, make sure you take the correct dosage of each supplement when stacking them with Adderall. Taking too much of either one could lead to adverse reactions or even overdose symptoms.

It’s best to start at a low dose and gradually increase as needed until you find the right balance for your body and mind.

By following these steps, you can ensure that you are choosing the right nootropic supplement to stack with Adderall to maximize its potential benefits while minimizing any potential risks.

What Are the Benefits of Stacking Nootropics With Adderall?

The benefits of stacking nootropics with Adderall are numerous.

First, they can help improve focus and concentration while reducing the potential side effects of Adderall, such as anxiety and irritability. Nootropics also have the potential to increase creativity, mental clarity, memory formation, recall, and sleep quality.

Additionally, stacking nootropics with Adderall can help to reduce fatigue and improve overall productivity. All of these benefits can positively impact your work or studies.

Stacking nootropic supplements with Adderall is a natural alternative to the potentially dangerous combination of prescription stimulants and alcohol that some people use to enhance their performance.

Overall, stacking nootropics with Adderall can provide a range of mental health benefits without risking your long-term well-being.

What Are the Side Effects of Stacking Nootropics With Adderall?

Although stacking nootropics with Adderall can provide many benefits, there are still potential side effects to consider.

The most common side effect is increased anxiety and irritability due to the stimulating effects of both Adderall and the nootropic supplements. However, nootropics like L-Theanine and Ashwagandha can help to reduce anxiety levels and counteract the side effects of Adderall.

Another potential side effect is elevated heart rate, blood pressure, and body temperature due to the stimulating combination of nootropics and Adderall. Therefore, monitoring your vital signs is important if you plan on stacking both of these substances.

It's also possible that some nootropic supplements may interact with Adderall and cause adverse reactions, so it's important to speak with your doctor before combining any prescription medications or dietary supplements.

To conclude, stacking nootropics with Adderall can provide numerous benefits without risking your long-term health.

Does Stacking Nootropics With Adderall Really Work?

So the question then becomes: Does stacking nootropics with Adderall actually work?

The short answer is yes. While the effects of individual nootropic supplements vary, when they are stacked with powerful stimulants like Adderall, the results can be even more powerful.

Studies have shown that combining nootropics with Adderall can improve focus, concentration, mental clarity, and productivity while reducing the potential side effects associated with Adderall.

That being said, it’s important to remember that each person’s body responds differently to different substances. Therefore, it’s essential to speak with your doctor before stacking any nootropics with Adderall.

By doing this, you can ensure that you’re taking the right supplements in the right dosages and maximizing the potential benefits of stacking nootropics with Adderall while minimizing any potential risks.

My Final Thoughts

If you’re looking to increase your productivity and focus while minimizing the potential side effects of Adderall, then stacking nootropics with Adderall can be a great option for you.

But if you're confused by the many different nootropic supplements out there, you can start with a nootropic blend as your foundation. I highly recommend Nooceptin, which contains a mixture of different nootropic ingredients that all go well with Adderall.

Overall, stacking nootropics with Adderall is a great way to enhance your focus and concentration while protecting your long-term health.

References
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  3. Di Perri, R et al. “A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia.” The Journal of international medical research vol. 19,4 (1991): 330-41. doi:10.1177/030006059101900406 ↑
  4. Baba, Yoshitake et al. “Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.” Journal of medicinal food vol. 24,4 (2021): 333-341. doi:10.1089/jmf.2020.4803 ↑
  5. Winnicka, Katarzyna et al. “Piracetam--an old drug with novel properties?.” Acta poloniae pharmaceutica vol. 62,5 (2005): 405-9. ↑
  6. Lapin, I. “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.” CNS drug reviews vol. 7,4 (2001): 471-81. doi:10.1111/j.1527-3458.2001.tb00211.x ↑
  7. Hall, Matthew et al. “Creatine Supplementation: An Update.” Current sports medicine reports vol. 20,7 (2021): 338-344. doi:10.1249/JSR.0000000000000863 ↑
  8. Gopukumar, Kumarpillai et al. “Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.” Evidence-based complementary and alternative medicine : eCAM vol. 2021 8254344. 30 Nov. 2021, doi:10.1155/2021/8254344 ↑