Dynamine Methylliberine Guide: What You Need To Know Before Buying

Written on May 18, 2023 by | Reviewed by William Gallagher, MNeuroSci

Dynamine Methylliberine is a natural alkaloid that is similar to caffeine that helps boost mental alertness, focus and energy levels. 

I came across an interesting Nootropic a couple of days ago. Or I shouldn't really call it a Nootropic since it's a natural alkaloid that is similar to caffeine but you know the drill.

I LOVE caffeine in the morning but absolutely HATE the fact that it makes me jittery.

So the thought of buying a Nootropic that potentially is similar to caffeine but without the side-effects is extremely interesting to me.

But before we dive into what Dynamine Methylliberine is I should add that I have NOT bought Dynamine just yet.

This article is meant to be a resource for everything Dynamine and is basically me trying to find as much information about the Nootropic as possible before I decide whether I want to buy it or not.

I figured it would be a good idea to dump everything I can find onto one page in the hopes that maybe some of you guys reading this would find it useful as well.

Anyways, I will start out with some basic information about it, then try to see if I can find some studies on PubMed and then finish it off with some anecdotes from people on Reddit who have tried it.

Here's what we will be covering today:

  • What is Dynamine Methylliberine?
  • What are the benefits and side effects?
  • How much should you take?
  • Can you stack it with other nootropics?
  • What other Reddit users are saying about Dynamine Methylliberine

So without further ado, let's get started!

What Is Dynamine Methylliberine?

Like caffeine, Dynamine is derrived from xanthine. Xanthine is a purine base that occurs naturally in our bodies.

What is different about Dynamine Methylliberine is that it's more powerful than other Xanthines and have a stronger impact on mood and energy levels.

From what I could find about Dynamine Methylliberine it's clear that if you take it by itself without stacking it with other nootropics the effects are relatively short-lived and aren't as intense as caffeine.

So be aware that if you're an avid coffee drinker like myself, the effects of Dynamine Methylliberine can be pretty lackluster compared to pure caffeine.

That's why some people on Reddit are recommending using Dynamine as a pre-workout supplement if you're training late in the evening.

Like other Nootropics the way Dynamine works is by activating receptors in the brain that are responsible for regulating adenosine receptors which have a direct impact on our feelings, mood and energy levels.

A guy from NootropicsDepot talks about Dynamine Methylliberine

What Are The Benefits & Side-Effects?

One of the downside with Dynamine is that there are very limited information about it since it's a relatively new Nootropic.

That being said I found an interesting study here looking at the safety & side-effects of short-term use with Dynamine Methylliberine alone and stacked with theacrine in healthy young adults.

This is the first study to look at the effects of Dynamine Methylliberine when taken alone and stacked with another nootrpic.

They measured heart rate, blood pressure, ECG and did blood work on the test subjects.

What they found was taking 100-150mg of Dynamine daily by itself or stacked with theacrine (25-50mg) had ZERO negative impact on health markers.

That being said the authors of the paper acknowledge that there are limitations to their research which they go more into details with right here.

In terms of benefits, here's what people say they experience when taking Dynamine:

  • They get 'a clean energy' like caffeine but without making them jittery
  • Dynamine Methylliberine kicks in faster and is more short-lived than caffeine
  • People report an overall enhanced mood, better focus and steady, clean energy

Can You Stack Dynamine Methylliberine With Caffeine?

Taken by itself Dynamine is a mediocre Nootropic at best. Stacking with caffeine however, is a totally different ball game.

When combined with caffeine is where Dynamine really shines.

Dynamine acts as a negative allosteric modulator on adenosine receptors with less tolerance buildup than caffeine (caffeine blocks adenosine receptors).

What this means is that Dynamine enhances the effects of caffeine by allowing a smaller amount of caffeine to block these receptors.

One great thing about this is that if you're looking to enhance the benefits and effects of caffeine (but without the need of taking more) you can stack a low dose of caffeine with Dynamine.

This also prevents all the negative side-effects that are associated with consuming too much caffeine (jittery being the big one).

I found a study on Pubmed showing that when you stack Dynamine Methylliberine with Caffeine it can extend the half-life of caffeine, which is pretty interesting.

What's The Best Dosage?

I couldn't really find anything conclusive when it comes to the right Dynamine Methylliberine dose to take.

That being said if we look at the study I posted above we can get a good sense of what an effective and safe dose would look like.

In the study they used the following dosages:

  • 100mg of Dynamine
  • 150mg of Dynamine
  • Dynamine stacked with TeaCrine (100mg Dynamine + 50mg TeaCrine)
  • Dynamine stacked with TeaCrine (150mg Dynamine + 25mg TeaCrine)

Dynamine Methylliberine comes in both powder and capsules. One capsule is 100mg which I would consider a low-dose.

On NootropicsDepot they recommend taking 1-2 capsules a day (100-200mg/day).

What Reddit Users Say About Dynamine Methylliberine


The first thread I could find on Reddit is by a user called; u/RevonM. The original post is just a short simple question where he asks people for more information about Dynamine.

What's interesting however, is the responses he gets in the thread.

One user says that he has tried Dynamine + Caffeine + Theanine and it has worked really well for him. He goes on to say that the Dynamine Methylliberine itself was the first thing to kick in or as he puts it:

"The Dynamine itself (Methylliberine) is the first thing that kicks in (really quickly) and was tremendously stimulating but no jitters."

The initial kick he got was then replaced by a 'stable energy' as he puts it. Which he says is probably due to the effects of caffeine and theanine.

He finishes off by saying that he hasn't tried Dynamine Methylliberine by itself but would be interested in testing it out.

Another Reddit user is sharing his first impression of Dynamine here.

He starts off by saying that prior to taking Dynamine he has had a 'pretty poor night of sleep".

He then decides to take Dynamine with Yerba.

The result surprised him.

A few hours after taking it he describes that he feels incredibly alert, motivated and focused. He goes on to say:

"There's definitely a dopaminergic feel to it...."

He then finishes off by giving an update after a few weeks saying that he has been taking Dynamine Methylliberine regularly and how pleased he is.

He then describes that he has experienced a slight tolerance buildup which is to be expected.

In Conclusion

Dynamine Methylliberine is a relatively new Nootropic with very limited information about it available.

Most of the data we have is from one study and anecdotes from people on Reddit and forums.

In terms of benefits taking Dynamine, people report that they experience better focus, get more energy and are more motivated.

When it comes to the safety profile of Dynamine Methylliberine, based on the study and anecdotes from people who have used it, it seems to be relatively safe with no side-effects.

Lastly, a low and safe dose of Dynamine is considered to be in the range; 50-100mg.