What does Cyclazodone do in your body?


Cyclazodone is a CNS stimulant with amphetamine-like and antidepressant effects. Biohackers use it for better focus, energy & increased motivation.


So I was doing some light research on a new potential Nootropic for a stack I’m currently trying to make and came across an interesting Smart Drug called; Cyclazodone. 

One of the things that I find interesting about Cyclazodone is that the effects have been compared to those of amphetamine (but without all the negative side effects).

This, obviously, made me want to dive a little bit deeper into it – especially since people are reporting better focus, sociability, and elevated mood when they take this stimulant.

So in this article I will take a closer look at the following;

  • What is Cyclazodone?
  • What does Cyclazodone do in the body?
  • What are the benefits and side effects?
  • Is Cyclazodone legal in your country?
  • What are people on Reddit saying about it?

…. So without further ado, let’s jump straight to it!



What is Cyclazodone?

As I briefly mentioned in the beginning, Cyclazodone is a central nervous system stimulant with amphetamine-like effects.

The chemical name is; 2-(cyclopropylamino)-5-phenyl-1,3-oxazole-4-one.

Cyclazodone was first synthesized back in the 60’s by an American company called; The American Cyanamid Company.

The idea behind Cyclazodone was to develop a safer CNS-stimulant to Pemoline and other similar derivatives.

Pemoline was used in the treatment of ADHD and narcolepsy but is no longer available in the US.

The FDA withdrew the approval of pemoline due to its negative side effects in children – some leading to liver failure.

Compared to Pemoline, Cyclazodone is a much safer CNS-stimulant. That being said, it is only available for research purposes in the US.

Cyclazodone is proven to be extremely effective as an energy booster and anorexigenic. It has unique features that sets it apart from other sympathomimetic drugs with less stimulatory activity and toxicity compared to amphetamines.



What does it do in the body?

Cyclazodone is a 4-oxazolidinone stimulant that produces focus enhancing, wakefulness and alertness effects.

Structurally it’s very similar to 4-methylaminorex.

When it comes to how it affects the body we have very limited data available.

That being said, it is speculated that it likely possesses hepatotoxic and other not known toxic effects.

We do, however, have some animal models where Cyclazodone has been shown to exhibit powerful CNS and antidepressant effects.

It also possesses anorexic efficacy and potency and the toxicity of cyclazodone is low compared to other amphetamine-like agonists.

Cyclazodone impacts the TAAR1-receptor in the brain. TAAR1 is a main regulator in serotonin, dopamine and noradrenaline.

This leads to the release of increased concentrations of these 3 neurotransmitters in the brain which in turn enhances cognition through better concentration, mood and energy levels.

What are the benefits and side effects?

It’s worth noting that most of the benefits and side effects experienced on Cyclazodone are anecdotal.

Since the data is limited I found some interesting reports on the Subjective Effect Index (SEI).

The Subjective Effect Index is basically just a huge collection of articles designed to serve as an in-depth reference work for the subjective effects people are experiencing when taking psychoactive substances.

Here’s what people are reporting in terms of the Benefits:

  • Stimulating – Weaker than methamphetamine, but stronger than Modafinil and caffeine.
  • Cognitive euphoria
  • Appetite suppression
  • Pain relief
  • Anxiety suppression
  • Empathy, affection, and sociability enhancement

Here’s what people are reporting in terms of the Side Effects:

  • Abnormal heartbeat
  • Nausea – only seems to occur when higher dosages are used
  • Teeth grinding- but less intense compared to amphetamines
  • Headaches – usually a sign of dehydration
  • Hypomania-like effects

The benefits it has on cognition is the main reason why people see Cyclazodone as a potent Nootropic with the only downside being the potential side effects.

In addition, when it comes to the toxicity and long-term use of Cyclazodone, we don’t have any studies (and only very limited history of human usage) which is why the exact toxic dose is still unknown.


Is it addictive?

Given the similarities that Cyclazodone and amphetamines have, a question that comes to mind is if Cyclazodone has addictive properties or not.

Whenever it comes to amphetamine-like stimulants, addiction is always a serious concern.

Compared to Pemoline, Cyclazodone doesn’t seem to show any addictive properties. That being said caution is always advised like it’s the case with all monoamine agents.

It’s worth noting that tolerance to the effects of it only seems to develop with prolonged use. Hence, why people need larger dosages in order to feel the effects.

If you stop taking Cyclazodone, it usually takes anywhere from 4 to 7 days for the tolerance to be reduced to half.

Is it legal in your country?

As is the case with most Smart Drugs, Cyclazodone is in a gray area when it comes to its legality.

This means that within certain parts of the world, its regulation is in a legal gray area (we don’t know if it’s illegal to possess or not).

That’s why some people can be charged for their possession while others won´t.

What we do know, however, is that in 2006 the World Anti-Doping Agency banned its use and put it on The Prohibited List.

From what I could find, Cyclazodone is not a controlled substance in;

  • Germany
  • Switzerland

This means that it may in some instances be considered legal. In the US it’s considered a Schedule IV controlled substance.


You can find Cyclazodone on Science.bio right here


What people on Reddit are saying about Cyclazodone


I thought it would be interesting to find 1 or 2 threads on Reddit to see what people that are actually taking Cyclazodone have to say.

I have linked to each thread so you can go over and read it for yourself.

The first thread I found is by a user called; u/-redan.

Redan starts off by saying that Cyclazodone is pretty amazing. He recently tried it and was impressed by the focus enhancement.

That being said, he did notice an anxiogenic effect.

He then goes on to say the following;

“There’s a noticeable mood lift, anti-anxiety effects, combined with strong focusing enhancement effects…”

He then finishes off by saying that tolerance buildup doesn’t seem to be a problem with N-Methyl-Cyclazodone and the other related compounds.

You can read the thread here

Another user called; u/Engenderling is talking about the negative side effects of N-Methyl-Cyclazodone.

The thread is a pretty detailed explanation of his Cyclazodone use.

You can read about his own personal experience here

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