Morphodrol: Benefits, Dosage & Side Effects (What You Need To Know)

Updated May 12, 2024 by | Reviewed by William Gallagher, MNeuroSci
(Estimated reading time: 3 minutes)

In this article I'll take a closer look at Morphodrol (also known as Morpholin-3-yl, Pipradrol and Meratran).

I'll explain what it is, its benefits, and if it has any potential side effects.

Morphodrol is a mild central nervous system stimulant (norepinephrine-dopamine reuptake inhibitor) that was developed in the 1940s and used for treating obesity.

It was subsequently used for the treatment of a variety of conditions such as narcolepsy, attention deficit hyperactivity disorder (ADHD), and most importantly: depression.

But what is Morphodrol exactly and how does it work in the brain? Let's take a closer look.

What is Morphodrol?

Morphodrol is a brand name for the drug Pipradrol, a stimulant used primarily to treat obesity and depression.

It was introduced in the early 1940s and soon became one of the most commonly prescribed weight-loss medications in Europe. However, over time its use declined due to issues with abuse potential.

Today it's still used in some European countries as well as the United States, although not often.

What does the drug do?

Morphodrol is a central nervous system stimulant; in other words, it increases alertness and reduces fatigue. It also enhances mood.

As previously mentioned it was first developed as an anti-obesity medication. It worked by reducing hunger and increasing energy expenditure. Eating less and moving more should lead to weight loss, right?

How does it work in the brain?

Morphodrol increases alertness by affecting neurotransmitters in the brain.

It inhibits the re-uptake of norepinephrine and dopamine, which are neurotransmitters involved in signaling alertness and mental focus.

By increasing these two neurotransmitters, Morphodrol can enhance alertness and decrease fatigue.

This is also the reason why it has become increasingly popular in the Nootropic community.

Morphodrol Benefits

Morphodrol has many benefits. First and foremost it's used to treat depression, a serious mental disorder that significantly impairs quality of life.

It increases the level of neurotransmitters that are involved in mental functioning, making people feel better both physically and mentally.

In addition to treating depression, Morphodrol can also improve overall brain function. Studies have shown it increased working memory, decision making, and attention span in healthy subjects.

It's also been shown to increase neuronal efficiency in neurological disorders affecting cognition such as Alzheimer's disease.

Side effects

Morphodrol does have some side effects, although generally they are mild and resolve themselves when use is discontinued.

The most common side effects include:

  • Increased heart rate
  • Headache, dizziness
  • Nervousness
  • Insomnia

It may also cause decreased appetite and dry mouth. All of these issues are usually mild but can become problematic if use is continued for an extended period of time.

In case you have any of these side effects initiate the quitting process as soon as possible.

Does it work as a Nootropic?

With its many benefits and low risk of side effects, it's no wonder that Morphodrol has become so popular as a Nootropic.

It's used in Europe and the United States mainly to treat depression but also to improve mental performance, which is why it has become a relatively common ingredient in some smart drugs.

Reports have shown it can increase working memory while also increasing alertness and reducing fatigue.

All of this makes it an excellent smart drug for someone suffering from ADHD, narcolepsy or depression.

Morphodrol has been compared to Adderall, but without the notorious side effects of amphetamines.

Where to buy it

Morphodrol is not as popular as other smart drugs, which means there is not a big selection when it comes to where you can buy it.

The best places are online supplement stores such as Newmind.

I've not personally ordered Morphodrol yet so I can't speak of the quality.

If you don't want to risk getting in trouble with the law you can find a better alternative to Morphodrol here.

What is the most optimal dosage?

The standard daily dosage of Morphodrol is 10-20 mg. However, recent research has shown that there is a relationship between weight loss and the optimal dosage.

The average weight loss in a controlled study with Morphodrol was 5.5%. In this study, the average dosage was 18 mg/day, which means about 7 mg/day more than the standard 20 mg/day dosage.

In Summary

Morphodrol is a great smart drug for people suffering from depression, ADHD or narcolepsy.

It's been shown to improve mental performance and is also very popular in the Nootropic community.

It can increase alertness and enhance focus. It's also known to reduce fatigue, making it a great product for people suffering from chronic fatigue syndrome or Parkinson's disease.

The optimal dosage is still being researched but most researchers agree that it's safe to take between 10-20 mg/day, depending on body weight.

If you don't want to risk getting in trouble with the law you can find a better alternative to Morphodrol here.