How Long Does Adrafinil Last?

Written on November 16, 2022 by | Reviewed by William Gallagher, MNeuroSci

The first question people often ask is "how long do the effects of adrafinil last?"

Adrafinil is a eugeroic medical drug that promotes and helps to increase alertness and prevent daytime sleepiness.

Controlled clinical trials have shown that it can be used to treat narcolepsy, for increased mental performance or as a healthy alternative to Adderall to boost brain activity.

In some clinical studies, the effects of adrafinil were reported to last for 10 to 12 hours when taken daily at a dosage of between 300 and 600 mg in the morning.

Adrafinil is considered one of the best Nootropics for focus and concentration, with a low potential for abuse, while also being a popular study drug.

However, it can cause some side effects. Which ones will depend on your personal biology and dosage levels.

It's important to remember that adrafinil affects everyone differently; there is no generic dosage that will fit everyone.

That being said, users typically report experiencing no side effects while on adrafinil.

Also, Adrafinil is a controlled substance in some countries and is sometimes being used as a weight-loss supplement to curb the appetite and without increasing blood pressure.

How Long Does a Single Dose of Adrafinil Last?

If you're going to take adrafinil only once a day, then the effects can last for up to 18 hours.

Blind randomized human studies have shown that the half-life of adrafinil is between 10 and 14 hours.

However, you can influence how quickly it's metabolized by your system with the dosage taken.

The more you take, the longer it will stay in your body which is important to remember if you don't want Adrafinil to interfere with your sleep.

It's also important to understand how quickly you metabolize adrafinil. People who are fast metabolizers may only get around 8 hours of effects from a single dose.

How Long Does Adrafinil Stay in Your System?

Adrafinil is broken down in the liver, so it can stay in your system for up to 36 hours.

However, because of this breakdown process, there are side effects associated with adrafinil metabolism too.

For example, you may experience headaches or nausea when taking adrafinil; these symptoms will gradually go away as the rate of metabolites in your system slows down.

Adrafinil can be detected for between 30 and 36 hours with a high sensitivity drug test.

How Long Does it Take For Adrafinil to Kick in?


Adrafinil is metabolized in the liver and takes effect most often after 45–60 minutes when taken orally on an empty stomach.

However, it can take between 90 minutes and two hours to have an effect if you eat before taking adrafinil.

If you're looking for a cognitive boost, then taking your adrafinil dose 45-60 minutes before breakfast is one of the best times to do so.

This way there's time for the adrafinil to absorb into your body before you need to focus on the day ahead.

When Does Adrafinil Peak?

According to certain research, plasma levels peak approximately 1 hour after 900 mg/kg of adrafinil is administered orally.

Adrafinil is considered effective after 45 – 60 minutes and can stay active in your system for up to 18 hours.

Adrafinil's bioavailability is approximately 80% regardless of whether it was taken on an empty stomach or not at all.

Bioavailability is the amount of a substance that enters circulation and is thus available for interactions with cells, tissues, or receptors.

How Do I Make Adrafinil Last Longer?

You can stack adrafinil with other nootropics such as Alpha GPC or CDP Choline.

Alpha GPC and CDP Choline are both cholinergic nootropics that can improve adrafinil's effects.

Cholinergic Nootropics are known to boost learning capacity, memory recall, and energy levels too.

This can help to make the experience last longer, while also reducing some of its negative side effects such as headaches and nausea.

It's also important to remember that adrafinil works best on an empty stomach for faster absorption into your system.

Adrafinil can also be stacked with Phenylpiracetam, Noopept, or Sunifiram.

If it's your first time taking adrafinil, it's not a good idea to stack with other nootropics.

Stick with 1 compound, assess how your body reacts to it, and then consider stacking with another nootropic the next time you take adrafinil.