5 Benefits of using Palmatine as a Nootropic

Updated May 13, 2024 by | Reviewed by William Gallagher, MNeuroSci
(Estimated reading time: 5 minutes)

Palmatine is a nootropic that can have powerful benefits for your brain.

It is a protoberberine alkaloid, most notably found in the rhizomes of Phellodendron amurense, and Coptis Chinensis.

It has many potential benefits, including; neuroprotectant properties that improve cognitive function and brain performance.

It can provide you with a calming effect that may help to reduce anxiety and stress levels as well as improving focus.

In this article, I'll explore 5 of the most important benefits of using Palmatine as a nootropic and why you should consider adding it to your stack!

So without further ado, let's just get started!

What is Palmatine?

As briefly mentioned earlier, Palmatine is a protoberberine alkaloid.

This means it contains the basic structure of a benzene ring and an isoquinoline group which is fused together with methylation on R-position.

Palmatine's structure is similar to many functionally important compounds such as; berberine and colchicine.

It is used to treat many health problems, including but not limited to; jaundice, dysentery, hypertension, and inflammation.

It is found naturally in some forms of traditional Chinese medicine where it has been used for centuries as a treatment for inflammatory diseases such as arthritis or hepatitis.

As well as this Palmatine can help improve your cognitive performance by improving memory recall and the ability to learn new things.

Let's take a look at 5 benefits you can expect from using Palmatine as a nootropic.

5. Neuroprotective benefits


Palmatine, a polyphenolic antioxidant used to treat Alzheimer's disease by inhibiting the activity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and neuraminidase-1 (NA-1).

The positively charged nitrogen atom in the isoquinoline ring of Palmatine is known to bind with AChE and BChE, inhibiting their activity.

This causes an increase in the concentration of acetylcholine (Ach) within the brain leading to improved cognitive function as well as neuroprotective properties.

4. Improved Cognitive Function & Brain Performance

Palmatine can increase your ability to learn new things and improve memory recall.

It does this by increasing the levels of acetylcholine (ACh) in your brain, which is a neurotransmitter responsible for many cognitive functions such as learning & memory.

In addition, Palmatine has been proven to have nootropic effects and can help to improve brain performance.

In one study it was found that Palmatine could reduce the rate of cognitive decline in patients suffering from Alzheimer's disease as well as improve learning, memory & retention capabilities.

These results suggest that this nootropic has a neuroprotective quality which is shown by its ability to protect neurons from free radicals.

This makes palmatine a great supplement for anyone looking to improve their memory, learning, and brain performance!

So if you're struggling with any of these cognitive problems there's no need to worry - Palmatine can help!

It also has the added benefit of decreasing stress which reduces your chances of suffering from burnout.

So if your current stack is not helping with these issues then try adding Palmatine to see how it can help.

3. Calming effect

Palmatine has a calming and relaxing effect that can help you to reduce stress levels.

This is in part due to the increase of Acetylcholine (ACh) within your brain, which activates serotonin receptors - this leads to an improved mood & feeling of calmness.

It may also be because of the GABAergic effect of Palmatine - GABA is a neurotransmitter responsible for reducing nerve impulses in your brain.

What this means is that it helps to calm down excitatory neurons which can lead to improved concentration and relaxation.

Many people are surprised by how strong this nootropic actually is, so you may want to start off with a smaller dose to see how it affects you.

If you are new to nootropics then Palmatine is an excellent starting point because of its high tolerability & safety levels, so there's nothing stopping you from trying this awesome supplement!

Palmatine can also help reduce fatigue by improving energy production in your body which allows you to stay awake for longer.

This can be especially useful if you're looking for a supplement that will help improve your learning and memory capabilities, as this is best achieved during the day when your mind is fresh & sharp!

2. Regulating blood lipid activity

Palmatine caused insulin release and insulin-mimicking activity to be induced in this study.

Palmatine also lowered lens aldose reductase, sucrase, and maltase activity in addition to inhibiting the activity of lens aldose reductase.

Palmatine decreased serum total cholesterol (TC) and triglycerides (TG) in rats with in vivo research, while increasing high-density lipoprotein cholesterol.

1. Anti-inflammatory activity

Palmatine can decrease the production of pro-inflammatory factors.

Palmatine's anti-inflammatory activity is the most studied of its properties and has been seen in several studies.

Inflammation in the body, and the brain, in particular, can cause serious damage and is a key factor in many diseases such as Alzheimer's, Parkinson's disease, and dementia.

This makes Palmatine an excellent choice for anyone who struggles with chronic inflammation or suffers from any of these conditions.

Palmatine also has the added benefit of being able to reduce blood pressure (BP), further enhancing its cognitive benefits.

Palmatine is a great supplement for anyone looking to improve their memory, learning, and brain performance!

What is the best dosage?

Palmatine is a relatively safe supplement and can be taken in doses of up to 200mg per day without any side effects.

It is best consumed on an empty stomach 30 minutes before you consume food, as it has been shown that Palmatine's bioavailability decreases when paired with foods such as bread or rice.

Palmatine can also be stacked with other nootropics such as Berberine to create an even stronger stack.

Here are some example stacks:

Berberine 500mg + Palmatine 200mg - This is a great combination to start with, as it can provide maximum benefits in terms of memory & learning while not causing any side effects.

What are the side effects of Palmatine?

As briefly mentioned, Palmatine is a very safe supplement with little to no reported side effects.

Some people have experienced mild nausea when they first started taking it, but this quickly subsided once their body got used to the dosage levels.

Palmatine may also cause you to feel slightly tired immediately after consumption, due in part to its GABAergic properties.

Palmatine is a great supplement to help improve cognitive performance and the best part is that its benefits can last for as long as two months after consumption!


What is Palmatine used for?

Palmatine has been used in traditional medicine in Asia to cure jaundice, liver-related illnesses, hypertension, inflammation, and dysentery.

What is protoberberine?

Protoberberine is a chemical that might be found in a variety of plants, including European barberry, goldenseal, goldthread, greater celandine, Oregon grape, Phellodendron, and tree turmeric.

Berberine is commonly used to reduce blood sugar levels, aid in the management of diabetes, treat high cholesterol and other fats (lipids) in the blood (hyperlipidemia), and treat high blood pressure.

Is Palmatine a Nootropic?

Palmatine is a natural nootropic supplement derived from the roots of several different species of barberry.

Nootropics are substances that can improve cognitive function such as memory, intelligence, motivation, attention, concentration and problem-solving.

Palmatine is known to improve the flow of blood & oxygen in the brain as well as reducing inflammation.