Agmatine Sulfate is a popular Nootropic that has been shown to boost the production of nitric oxide synthase as well as mental clarity and energy.
Agmatine sulfate is an organic compound that is obtained from animals, bacteria, and plants.
Other names of agmatine scientifically used are Decarboxylated arginine, Agmatine, and Guanidine.
Agmatine has major effects on the brain and nervous system of a human.
How Does Agmatine Sulfate Affect The Body?
The exact role of agmatine sulfate in the human body is still not discovered by scientists.
The important thing known about it is that it has a significant role in metabolic functions. It has also been found that it affects the functioning of the nervous system and helps with anxiety and depression.
It is a compound that has its effects on various enzymes and receptors in the body. It is present in the highest amount in the gut where it is produced by bacteria living there.
Right after entering the body, agmatine targets the central and peripheral nervous systems.
Agmatine sulfate activates both of these systems which results in a mild reduction in heart rate and blood pressure.
Agmatine sulfate acts on its various molecular targets which include norepinephrine release, NO-production, and imidazoline receptors subtypes.
Agmatine sulfate also has its effects on the kidney.
It increases the rate of glomerular filtration and exerts nephroprotective effects on the kidney.
Agmatine sulfate has a role in glucose regulation.
Its effects are due to the modulation of various molecular mechanisms that regulates blood glucose regulation.
The Central Nervous System
Agmatine has also been considered a neurotransmitter.
Agmatinase enzyme is the one that inactivates its functioning. Agmatine is produced in the brain cells and stored in synaptic vesicles.
Agmatine binds to a specific receptor and to imidazoline receptor binding sites which result in the blockade of the NMDA receptor’s activity.
Since agmatine works on Henry Dale’s criteria of neurotransmitter thus it is called a co transmitter or a neuromodulator.
Nitric Oxide Synthase
Agmatine is present naturally in many cells of the body where it has many important cellular functions to perform.
In order to find out its mechanism, researchers have performed experiments on humans, various animals, and bacteria.
It has been found out that Agmatine sulfate restricts the production of Nitric Oxide Synthase (an enzyme that produces nitric oxide). These nitric oxide synthase enzymes are of three types:
- One of which is iNOS (inducible) which is responsible for the production of large among of Nitric oxide. Larger production of this enzyme may cause inflammation.
- Another important enzyme is nNOS which is neuronal and is mainly responsible for the signaling between different neurons across the brain and acts as a messenger. If not checked, this may inhibit the repair and growth of neurons.
- The third type of enzyme is eNOS found in endothelial. It is responsible for the signaling of vasodilation to help increase blood flow. Blood pressure lowers as the blood flow increases along with an increase in the import of oxygen and other nutrients.
Scientists, therefore, suggest that agmatine is responsible for the regulation of nitric oxide levels by inhibiting the production of the above-mentioned enzymes.
Some research on agmatine on animals has proven that it has a role in treating illnesses like stress, anxiety, and depression.
Taking agmatine as per the doctor’s instructions can help you control these illnesses.
In the case of depression, agmatine sulfate acts by completely removing the depressive system.
This occurs in the blocking of NMDA receptors and not through the pathways of serotonin.
Stroke is a nervous system disorder in which the blood vessel leading to the brain is blocked.
Agmatine can protect a person from stroke by inhibiting the enzymes; iNOS and nNOS and increasing eNOS. An Increase in eNOS can help the flow of blood to continue to the brain.
This research, however, is limited to mice only and not yet proven on humans.
Furthermore, the effects of agmatine on tumor cells are under research. In fact, they are in their early stages.
Several tests on mice have indicated that agmatine prevented the growth of tumor cells in the connective tissue in mice.
Transparents Lab Agmatine supplements are considered among one of the best agmatine sulfate tablets. 1 tub of these supplements contains 100 tablets, 1g with each serving.
One scoop of this supplement is taken with 8-10 ounces of water just before the workout.
Not only does this supplement helps in bodybuilding, but it also has its role in boosting the process of healing, curing mental illnesses like stress, anxiety, depression, and regulation of blood pressure, blood glucose level.